Photo, pH and redox multi-responsive nanogels for drug delivery and fluorescence cell imaging

Chen, Shuo; Bian, Qing; Wang, Panjun; Zheng, Xiaodong; Lv, Le; Dang, Zhi‐Min; Wang, Guojie

doi:10.1039/c7py01424d

Cited by 98 publications

(104 citation statements)

References 60 publications

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“…Aer concentration, the modied polymer was precipitated in excess cold diethyl ether. The copolymer HONB-P(aN 3 CL) 10 was obtained at a 91% yield. Fig.…”

Section: Methodsmentioning

confidence: 99%

“…Fig. 1A and 2A depict the representative 1 H NMR and infrared (IR) spectra of HONB-P(aN 3 CL) 10 , respectively.…”

Section: Methodsmentioning

confidence: 99%

“…Fig. 2 IR spectra of (A) HONB-P(aN 3 CL) 10 , (B) HONB-P(aN 3 CL-g-PONBIMC) 10 , (C) Gluco-ONB-P(aN 3 CL-g-PONBIMC) 10 . ) was dissolved in 10 mL of dry DMF, followed by the addition of excess NaN 3 (1.01 g, 15.53 mmol).…”

Section: Methodsmentioning

confidence: 99%

“…The residue was puried by ash column chromatography with hexane/EA (5 : 1) to give 2-propargyoxymethyl pyrene (1.51 g, 65% yield). 1 10 , (B) (4-propargoxy-2-nitro)benzyl indomethacinoate (PONBIMC), (C) HONB-P(aN 3 CL-g-PONBIMC) 10 , and (D) Gluco-ONB-P(aN 3 CL-g-PONBIMC) 10 . Fig.…”

Section: Methodsmentioning

confidence: 99%

“…First, a mixture of HONB- Fig. 3 GPC curve of (A) HONB-P(aN 3 CL) 10 , (B) HONB-P(aN 3 CL-g-PONBIMC) 10 , and (C) Gluco-ONB-P(aN 3 CL-g-PONBIMC) 10 . The puried polymers Glyco-ONB-P(aN 3 CL-g-alkyne) n were dried in vacuo at 60 C for 24 h to be obtained in 56-91% yield and analyzed.…”

Section: Methodsmentioning

confidence: 99%

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Photo-responsive polymeric micelles and prodrugs: synthesis and characterization

et al. 2018

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Bio-recognizable and photocleavable amphiphilic glycopolymers and prodrugs containing photodegradable linkers (i.e. 5-hydroxy-2-nitrobenzyl alcohol) as junction points between biorecognizable hydrophilic glucose (or maltose) and hydrophobic poly(a-azo-3-caprolactone)-grafted alkyne or drug chains were synthesized by combining ring-opening polymerization, nucleophilic substitution, and "click" post-functionalization with alkynyl-pyrene and 2-nitrobenzyl-functionalized indomethacin (IMC). The block-grafted glycocopolymers could self-assemble into spherical photoresponsive micelles with hydrodynamic sizes of <200 nm. Fluorescence emission measurements indicated the release of Nile red, a hydrophobic dye, encapsulated by the Glyco-ONB-P(aN 3 CL-galkyne) n micelles, in response to irradiation caused by micelle disruption. Light-triggered bursts were observed for IMC-loaded or -conjugated micelles during the first 5 h. Following light irradiation, the drug release rate of IMC-conjugated micelles was faster than that of IMC-loaded micelles. Selective lectin binding experiments confirmed that glycosylated Glyco-ONB-P(aN 3 CL-g-alkyne) n could be used in biorecognition applications. The nano-prodrug with and without UV irradiation was associated with negligible levels of toxicity at concentrations of less than 30 mg mL À1. The confocal microscopy and flow cytometry results indicated that the uptake of doxorubicin (DOX)-loaded micelles with UV irradiation by HeLa cells was faster than without UV irradiation. The DOX-loaded Gluco-ONB-P(aN 3 CL-g-PONBIMC) 10 micelles effectively inhibited HeLa cells' proliferation with a half-maximal inhibitory concentration of 8.8 mg mL À1.

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“…Aer concentration, the modied polymer was precipitated in excess cold diethyl ether. The copolymer HONB-P(aN 3 CL) 10 was obtained at a 91% yield. Fig.…”

Section: Methodsmentioning

confidence: 99%

“…Fig. 1A and 2A depict the representative 1 H NMR and infrared (IR) spectra of HONB-P(aN 3 CL) 10 , respectively.…”

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Photo-responsive polymeric micelles and prodrugs: synthesis and characterization

et al. 2018

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Concept Design of Transdermal Microneedles for Diagnosis and Drug Delivery: A Review

2021

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Microneedles (MNs) are one of intriguing approach for efficient transdermal drug delivery that penetrates the protective skin barrier in a painless and less invasive way. In recent years, multidisciplinary studies have been conducted to improve their properties to meet stringent requirements and obtain market release approval. This review aims to summarize the latest concept design with unique properties in the advancement of transdermal MNs for diagnosis and therapeutic application. Numerous significant innovation strategies in improving MNs in aspects of adhesion ability, dosing capacity, drug‐controlled release, diffusion control ability, site‐targeted and on‐demand drug delivery, and biomarker or drug release monitoring are presented. Given that the majority of technologies used in such design are exclusively laboratory‐based, striving toward commercialization is a critical aspect of the revolution. Key challenges and future perspectives in industrial and economic aspects are identified with the intention of translating the reviewed technologies into marketable products.

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Translating Therapeutic Microgels into Clinical Applications

Kittel

Kuehne

Laporte

2021

Adv Healthcare Materials

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Microgels are crosslinked, water‐swollen networks with a 10 nm to 100 µm diameter and can be modified chemically or biologically to render them biocompatible for advanced clinical applications. Depending on their intended use, microgels require different mechanical and structural properties, which can be engineered on demand by altering the biochemical composition, crosslink density of the polymer network, and the fabrication method. Here, the fundamental aspects of microgel research and development, as well as their specific applications for theranostics and therapy in the clinic, are discussed. A detailed overview of microgel fabrication techniques with regards to their intended clinical application is presented, while focusing on how microgels can be employed as local drug delivery materials, scavengers, and contrast agents. Moreover, microgels can act as scaffolds for tissue engineering and regeneration application. Finally, an overview of microgels is given, which already made it into pre‐clinical and clinical trials, while future challenges and chances are discussed. This review presents an instructive guideline for chemists, material scientists, and researchers in the biomedical field to introduce them to the fundamental physicochemical properties of microgels and guide them from fabrication methods via characterization techniques and functionalization of microgels toward specific applications in the clinic.

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Photo, pH and redox multi-responsive nanogels for drug delivery and fluorescence cell imaging

Abstract: A light, pH and redox triple-responsive spiropyran-based nanogel is prepared and applied for the efficient delivery of anticancer drugs and fluorescence cell imaging for the strong emission of merocyanine photoisomers.

Cited by 98 publications

References 60 publications

Photo-responsive polymeric micelles and prodrugs: synthesis and characterization

Photo-responsive polymeric micelles and prodrugs: synthesis and characterization

Concept Design of Transdermal Microneedles for Diagnosis and Drug Delivery: A Review

Translating Therapeutic Microgels into Clinical Applications

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