Photo-induced treatment of breast epithelial cancer cells using nanostructured titanium dioxide solution

Synthesis, characterization and in vitro photodynamic study of FA-TiO2 nanocomposite

“…This result suggested that cell cycle arrest was involved in the photodynamic killing effect. Our observations are quite paralleled with that of other investigators, who propose a cell cycle arrest in breast epithelial cancer cells upon treatment of bare TiO 2 NPs under UV irradiation [8].…”

“…Furthermore, PDT exhibits minimal invasiveness, because the resulting photodynamic effect can be limited to the focal zone leaving the surrounding healthy tissues undamaged [3]. Therefore, PDT was considered as a relatively safe treatment for many malignancies, such as skin [4], brain [5], gastrointestinal [6], and gynecological cancers [7,8].…”

Nanoparticles in biomedical applications

“…TiO 2 nanoparticles have many unique properties such as biocompatibility, chemical stability and optical properties [173]. It is because of these properties that there has been a recent increase in the use of TiO 2 nanoparticles in biomedical applications such as drug delivery [174][175][176][177][178][179], bioimaging [175], photoablation therapy [180][181][182][183][184][185] and biosensors [186,187], which will be discussed further in Section 4. Other metal oxide nanoparticles that are gaining interest in biomedical applications are cerium oxide (CeO 2 ) nanoparticles or nanoceria.…”

“…The results showed that the toxicity effect of TiO 2 nanoparticles on the cells is cell dependent as there was no effect detected on the MCF-7 cells, whereas for the same concentration, cell apoptosis was detected for MDA-MB-436 cell line. Further work is needed to optimise this photocatalytic cancer treatment as UVA irradiation can damage healthy cells [180]. The photoexcitation of TiO 2 nanoparticles was investigated to inhibit the growth of malignant glioma cells by Wang et al [181].…”

“…TiO 2 has many unique features such as good biocompatibility, low toxicity, chemical stability and photocatalytic properties which makes it an attractive material for use in the biomedical industry. Due to its unique properties, lots of research has been carried out on using TiO 2 nanoparticles in different biomedical applications such as drug delivery, PDT, cell imaging, biosensors and genetic engineering [173][174][175][176][177][178][179][180][181][182][183][184][185][186][187]. In this review, we will discuss the use of TiO 2 nanoparticles in targeted drug delivery and PDT.…”