Photo-induced synthesis of molybdenum oxide quantum dots for surface-enhanced Raman scattering and photothermal therapy

Yu, Hongfeng; Zhuang, Zhengfei; Li, Dongling; Guo, Yanxian; Li, Yang; Zhong, Huiqing; Xiong, Honglian; Liu, Zhiming; Guo, Zhouyi

doi:10.1039/c9tb02102g

Cited by 29 publications

(32 citation statements)

References 48 publications

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“…2 A and Additional file 1 : Fig. S7), which is consistent with the reported data and facilitates synergistic cancer treatment [ 28 , 29 ]. Furthermore, the FA-BSA-PEG/MoOx retained its excellent photothermal performance without any perceptible attenuation even after five cycles of exposure to NIR irradiation (Fig.…”

Section: Resultssupporting

confidence: 89%

A molybdenum oxide-based degradable nanosheet for combined chemo-photothermal therapy to improve tumor immunosuppression and suppress distant tumors and lung metastases

et al. 2021

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Molybdenum oxide (MoOx) nanosheets have drawn increasing attention for minimally invasive cancer treatments but still face great challenges, including complex modifications and the lack of efficient accumulation in tumor. In this work, a novel multifunctional degradable FA-BSA-PEG/MoOx nanosheet was fabricated (LA-PEG and FA-BSA dual modified MoOx): the synergistic effect of PEG and BSA endows the nanosheet with excellent stability and compatibility; the FA, a targeting ligand, facilitates the accumulation of nanosheets in the tumor. In addition, DTX, a model drug for breast cancer treatment, was loaded (76.49%, 1.5 times the carrier weight) in the nanosheets for in vitro and in vivo antitumor evaluation. The results revealed that the FA-BSA-PEG/MoOx@DTX nanosheets combined photothermal and chemotherapy could not only inhibit the primary tumor growth but also suppress the distant tumor growth (inhibition rate: 51.7%) and lung metastasis (inhibition rate: 93.6%), which is far more effective compared to the commercial Taxotere®. Exploration of the molecular mechanism showed that in vivo immune response induced an increase in positive immune responders, suppressed negative immune suppressors, and established an inflammatory tumor immune environment, which co-contributes towards effective suppression of tumor and lung metastasis. Our experiments demonstrated that this novel multifunctional nanosheet is a promising platform for combined chemo-photothermal therapy. Graphical Abstract

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Section: Resultssupporting

confidence: 89%

A molybdenum oxide-based degradable nanosheet for combined chemo-photothermal therapy to improve tumor immunosuppression and suppress distant tumors and lung metastases

et al. 2021

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“…Additional to biosensing, therapeutic functions have also been achieved. Particularly, NIR-responsive semiconductors are extensively used in photothermal treatment (PTT) of cancerous cells, including hydrous RuO2, WS2, copper chalcogenides and Mobased materials 72,[118][119][120][121][122] . Photo-tuned MoO2 quantum dots with varied optical response in the NIR region are a good example of dual-functional SERS substrates 122 , with SERS activity towards bioactive molecules phenylalanine and amphotericin, while also showing good PTT performance towards cancer cell HEP G2.…”

Section: Ex Situ Sensingmentioning

confidence: 99%

Defect engineering in semiconductor-based SERS

2022

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“…[38,39] Thus, the MoO 3-x nanomaterials were applied in photothermal removal of cancer. [40][41][42] The convenient way to obtain MoO 3-x nanomaterials is to separate from bulk oxide [17] MoO 3 powders with an exfoliation process, which is time consuming and low yield. Generally, the extraction of MoO 3-x nanoparticles can be classified as two categories: hydrothermal and chemical exfoliation.…”

Section: Introdutionmentioning

confidence: 99%

Morphology‐controlled Synthesis of Molybdenum Oxide with Tunable Plasmon Absorption for Phothermal Therapy of Cancer

Zhang

Guo

et al. 2020

ChemNanoMat

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Semiconductor nanocrystals showing surface plasmonic absorption features can be used as prospective substitutes for noble metallic nanoparticles. Herein, a creative one‐pot hydrothermal route without template is used to synthesize plasmonic oxygen deficiency molybdenum oxide (MoO3‐x) nanoparticles. The morphologies of as‐prepared MoO3‐x nanomaterials arranged from amorphous to crystalline with the reaction temperature varied from 160 °C, 180 °C to 200 °C, namely MoO3‐x quantum dots (QDs), MoO3‐x nanosheets, and MoO2 nanospheres. Simultaneously, in the near‐infrared region (NIR), MoO3‐x nanomaterials exhibit gradually enhanced localized surface plasmon resonance (LSPR) absorption, of which MoO2 nanospheres exhibit intense NIR absorption with a photothermal conversion efficiency up to 72.5% under 808 nm NIR laser irradiation. Moreover, the toxicity and cancer therapy efficacy of MoO2 nanospheres have been systematically assessed in vitro and in vivo, respectively. The results revealed that MoO2 nanospheres exhibit low toxicity and high therapeutic efficiency, making it an promising and effective photothermal agent in photothermal therapy

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Photo-induced synthesis of molybdenum oxide quantum dots for surface-enhanced Raman scattering and photothermal therapy

Abstract: By means of a simple and photo-induced method, four colors of molybdenum oxide quantum dots (MoOx QDs) have been synthesized for surface-enhanced Raman scattering and photothermal therapy.

Cited by 29 publications

References 48 publications

A molybdenum oxide-based degradable nanosheet for combined chemo-photothermal therapy to improve tumor immunosuppression and suppress distant tumors and lung metastases

A molybdenum oxide-based degradable nanosheet for combined chemo-photothermal therapy to improve tumor immunosuppression and suppress distant tumors and lung metastases

Defect engineering in semiconductor-based SERS

Morphology‐controlled Synthesis of Molybdenum Oxide with Tunable Plasmon Absorption for Phothermal Therapy of Cancer

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