Photo-induced decarboxylative hydroacylation of α-oxocarboxylic acids with terminal alkynes by radical addition–translocation–cyclization in water

Abstract

A green and efficient photo-induced radical addition-translocation-cyclization (RATC) reaction of terminal alkynes and α-oxocarboxylic acids has been developed. Without the addition of any external catalyst or oxidant, this method provides...

Visible photons as ideal reagents for the activation of coloured organic compounds

“…The latter intermediate coupled with radical anions 26.5a-e, resulting in the formation of acyl hydrazines 26.3a-e through the protonation of the anions 26.6a-e. 139 Acyl radicals arising from a-ketoacids have also been employed for the synthesis of multi-functionalized cyclopentane scaffolds via tandem radical addition on terminal alkynes, translocation and cyclization in water. 140 3.2.2. Aryl radicals.…”

“…Acyl radicals arising from α-ketoacids have also been employed for the synthesis of multi-functionalized cyclopentane scaffolds via tandem radical addition on terminal alkynes, translocation and cyclization in water. 140…”

Synthesis of 2,2,6,6-Tetramethylpiperidin-1-yl-2-(2-cyanophenyl)-acetate by Transition Metal-Free Radical Cleavage Reaction from α-Bromoindanone

“…根据实验结果并参阅文献 [22], 提出了可能的反应 机理, 并通过密度泛函理论在 M06-2X/6-311g(d,p)的水 平下计算进行了验证(图 4) [23] . 该反应可能经历了较为 少见的碱促进碳-碳键均裂生成羰基-亚胺双自由基中 间体, 随后被 TEMPO 捕获生成(2-氰基苯基)乙酸的反 应历程 [24] . 首先溴代茚酮 1a 在叠氮化钠作用下生成…”