Photo-Enhanced Delivery of Genetic Material Using  Curcumin Loaded Composite Nanocarriers

Bakowsky, Udo

doi:10.25107/2474-1663.1323

Cited by 4 publications

(3 citation statements)

References 30 publications

(29 reference statements)

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“…Another important aspect in determining biocompatibility, with respect to intravenous administrations, is the effect on blood coagulation time. The activated partial thromboplastin time helps determine the safety profile of the formulation in terms of a possible increase in the coagulation time [25]. The hybrid vectors used in this study showed only a marginal increase in the clotting time (by 2–3 s compared to the blanks).…”

Section: Resultsmentioning

confidence: 99%

Glycosylated Artificial Virus-Like Hybrid Vectors for Advanced Gene Delivery

2019

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The major obstacle facing efficient gene therapy is the development of reliable delivery vehicles, which are both nontoxic and biocompatible and possess efficient cell-specific gene delivery. Previously, hybrid delivery vehicles comprising anionic liposomes and cationic polymers have been used successfully for gene therapy. In this study, hybrid vectors based on glycosylated artificial viral envelopes (including two novel compositions mimicking HIV and HSV envelopes) and polyethylenimine were morphologically and physiologically characterised. Transfection studies showed that the hybrid vectors based on the control liposomes, and their glycosylated modifications, had significantly higher transfection rates compared to the polyplexes. Improvement in the transfection efficiency was observed with the glycosylated HIV- and HSV-mimicking hybrid vectors, which also showed a safe biocompatibility profile based on the cytotoxicity and haemocompatibility assays. These glycosylated artificial viral envelope-based hybrid vectors could be used as safe gene delivery systems with potential to become new compositions for efficient nonviral gene therapy.

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Section: Resultsmentioning

confidence: 99%

Glycosylated Artificial Virus-Like Hybrid Vectors for Advanced Gene Delivery

2019

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“…Additionally, the encapsulation of indocyanine Green (ICG) in chitosan-coated liposomes gave stable liposomes, enhanced their uptake by B16-F10 melanoma cancer cells, and increased and improved phototoxicity . According to another study, a novel multimodal delivery system using curcumin-loaded lipopolyplexes (LPPs) in combination with PDT was created, and it enhanced the delivery of RNA molecules to the SKOV-3 cancer cell . In a different study, curcumin was loaded into liposomes made of HSPC and DPPE-mPEG5000, which improved the stiffness of the liposomal bilayer membrane, prevented curcumin from leaking outside the lipid membranes, and led to increased cytotoxicity toward cancer cells .…”

Section: Phototriggered Liposomes In Cancer Chemotherapy and Immunoth...mentioning

confidence: 99%

“… 61 According to another study, a novel multimodal delivery system using curcumin-loaded lipopolyplexes (LPPs) in combination with PDT was created, and it enhanced the delivery of RNA molecules to the SKOV-3 cancer cell. 62 In a different study, curcumin was loaded into liposomes made of HSPC and DPPE-mPEG5000, which improved the stiffness of the liposomal bilayer membrane, prevented curcumin from leaking outside the lipid membranes, and led to increased cytotoxicity toward cancer cells. 63 Another study reported the fabrication of photoresponsive liposomes that contained both the anticancer medication cisplatin and ICG.…”

Section: Phototriggered Liposomes In Cancer Chemotherapy and Immunoth...mentioning

confidence: 99%

A Snapshot of Photoresponsive Liposomes in Cancer Chemotherapy and Immunotherapy: Opportunities and Challenges

Youness,

Mohamed,

Efthimiadou

et al. 2023

ACS Omega

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To provide precise medical regimens, photonics technologies have been involved in the field of nanomedicine. Phototriggered liposomes have been cast as promising nanosystems that achieve controlled release of payloads in several pathological conditions such as cancer, autoimmune, and infectious diseases. In contrast to the conventional liposomes, this photoresponsive element greatly improves therapeutic efficacy and reduces the adverse effects of gene/drug therapy during treatment. Recently, cancer immunotherpay has been one of the hot topics in the field of oncology due to the great success and therapeutic benefits that were well-recognized by the patients. However, several side effects have been encountered due to the unmonitored augmentation of the immune system. This Review highlights the most recent advancements in the development of photoresponsive liposome nanosystems in the field of oncology, with a specific emphasis on challenges and opportunities in the field of cancer immunotherapy.

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Synergic effect between TRAIL gene and curcumin in magnetic chitosan nanoparticles on cancer cells apoptosis enhanced by laser photoactivation

et al. 2022

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The Apoptosis is an intensely studied mechanism for cancer therapy. Various genes, drugs, and molecules have been combined to potentiate the apoptotic effect against tumor cells. Magnetic nanocomplexes with biopolymers have been proposed as nanocarriers for delivery of active molecules and improve apoptosis induction. To these purpose were formulated magnetic nanoparticles with curcumin coated chitosan (MNPs-CHI-TPP-CUR) and magnetic nanoparticles with pCEM-TRAIL plasmid coated chitosan (MNPs-CHI-TPP-TRAIL) for use alone or in combination to induce the apoptosis of B16F10 tumor cells because curcumin is capable of overexpressing receptors TRAIL required for apoptosis induction. Also, curcumin (CUR) has been used as a photosensitizer in photodynamic therapy (PDT). In this work, it was produced and characterized nanoparticles with curcumin and nanoparticles with TRAIL gene. Both types of nanoparticles were ~ 200 nm size. The results showed that the combination of (MNPs-CHI-TPP-CUR) and (MNPs-CHI-TPP-TRAIL) induced a significant increase in cellular death within 48 h compared with the effect of each nanocomplex individually, demonstrating a synergic effect. This is the first description the synergic interaction between TRAIL gene and curcumin drug to improve the apoptosis in cancer cells. Also, it was determined that cellular death was potentiated when the treated cells were exposed to laser photoactivation with wavelengths of 405 nm and 532 nm for 15 min. Graphical abstract

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Photo-Enhanced Delivery of Genetic Material Using Curcumin Loaded Composite Nanocarriers

Cited by 4 publications

References 30 publications

Glycosylated Artificial Virus-Like Hybrid Vectors for Advanced Gene Delivery

Glycosylated Artificial Virus-Like Hybrid Vectors for Advanced Gene Delivery

A Snapshot of Photoresponsive Liposomes in Cancer Chemotherapy and Immunotherapy: Opportunities and Challenges

Synergic effect between TRAIL gene and curcumin in magnetic chitosan nanoparticles on cancer cells apoptosis enhanced by laser photoactivation

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