Photo-degradation of the antimicrobial ciprofloxacin at high pH: Identification and biodegradability assessment of the primary by-products

Vasconcelos, Tibiriçá G.; Henriques, Danielle M.; König, Armin; Martins, Ayrton F.; Kümmerer, Klaus

doi:10.1016/j.chemosphere.2009.03.022

Cited by 188 publications

(75 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Thus, the total toxicity of remaining ciprofloxacin and formed photo-products had been reduced, i.e. the toxicity of the photo-products was probably no higher than that of ciprofloxacin itself (Vasconcelos et al, 2009). Ge et al (2010) studied the aquatic photochemistry of fluoroquinolones and the toxicity of the oxidation products as well as luminescence inhibition to Vibrio fischeri.…”

Section: Ecotoxicitymentioning

confidence: 99%

See 1 more Smart Citation

Environmental contamination by fluoroquinolones

Frade

Dias

Teixeira

et al. 2014

Braz. J. Pharm. Sci.

141

View full text Add to dashboard Cite

Over the past few decades, a high number of pharmaceuticals have been detected in surface, ground and drinking waters. This contamination comes from domestic sewage, livestock, hospitals and chemicalpharmaceutical industries. Typical examples of these pollutants are the fluoroquinolones -powerful antibiotics used in human and veterinary medicine. The presence of fluoroquinolones in the environment can pose a serious threat to the ecosystem and to human health due to their high consumption globally: in 1998, around 120 tons were produced. Even at low environmental concentrations, antibiotics stimulate bacterial resistance. The consequences of the presence of fluoroquinolones in the environment are not fully understood, but are known to be toxic to plants and aquatic organisms. Approximately 85% of the fluoroquinolones present in influents can be removed by conventional wastewater treatment plants, but the removed fraction is frequently accumulated in the sludge, which is sometimes used as fertilizer, representing an additional input route into the environment. The removal of fluoroquinolones by biological treatment is ineffective, and it is believed that only advanced oxidation technologies are able to destroy these emerging pollutants.Uniterms: Fluoroquinolones/waste/environmental impact. Fluoroquinolones/waste/environmental contamination. Environmental contamination. Advanced oxidation processes/wastewater treatment.Nas últimas décadas, um grande número de fármacos tem sido identificado em águas superficiais, subterrâneas e potáveis. Tal contaminação advém do esgoto doméstico, hospitais, criação de animais e das indústrias químico-farmacêuticas. Exemplos típicos desses poluentes são as fluoroquinolonaspotentes antibióticos empregados na medicina humana e veterinária. A presença de fluoroquinolonas no meio ambiente pode representar uma séria ameaça para o ecossistema e para a saúde humana devido ao alto consumo mundial: em 1998 foram produzidas, aproximadamente, 120 toneladas. Mesmo em baixas concentrações, antibióticos podem estimular a resistência bacteriana. As consequências da presença de fluoroquinolonas no ambiente não são completamente compreendidas, mas sabe-se que são tóxicas para plantas e organismos aquáticos. Aproximadamente 85% das fluoroquinolonas presentes em efluentes podem ser removidos em estações de tratamento de efluentes convencionais, porém a fração removida é frequentemente acumulada no lodo, muitas vezes usado como fertilizante, o que representa uma rota adicional de entrada desses compostos no ambiente. A remoção de fluoroquinolonas por meio de tratamento biológico não é eficiente, e acredita-se que somente as tecnologias de oxidação avançada sejam capazes de degradar esses poluentes emergentes.Uniterms: Fluorquinolonas/resíduos/impacto ambiental. Fluorquinolonas/resíduos/contaminação ambiental. Contaminação ambiental. Processos oxidativos avançados/tratamento de águas residuais.

show abstract

Section: Ecotoxicitymentioning

confidence: 99%

“…Vasconcelos et al (2009) studied the photodegradation of ciprofloxacin, identifying the primary by-products, and assessed their biodegradability and toxicity. The photo-products were obtained by irradiation with a medium-pressure mercury arc lamp.…”

Section: Ecotoxicitymentioning

confidence: 99%

Environmental contamination by fluoroquinolones

Frade

Dias

Teixeira

et al. 2014

Braz. J. Pharm. Sci.

141

View full text Add to dashboard Cite

show abstract

“…The continuously decrease of toxicity during CWAO was possibly caused by the consumption of the catalysts used, the substantial decomposition of ENR and generation of less toxic products. However, some studies showed an increase trends of toxicity after ozonation or photodegradation of several types of antibiotics (Vasconcelos et al, 2009;Ge et al, 2010;Homem and Santos, 2011). This encourages further optimization of CWAO as treatment technique for wastewater loaded with quinolones.…”

Section: Biodegradability and Toxicity Of Reaction Mixture By Cwaomentioning

confidence: 99%

“…generated compound 11 (Guinea et al, 2010). The antimicrobial activity of fluoroquinolones was believed to derive from the quinolone moiety (Vasconcelos et al, 2009). As described in Scheme 1, most existing intermediates still exhibited an intact quinolone core with carboxylic acid group, fluoride and intact piperazine ring on position 7.…”

Section: Proposed Primary Degradation Products and Reaction Pathwaysmentioning

confidence: 99%

“…BOD 5 /COD ratio is often used to express the biodegradability of wastewater, where a value of zero indicates non-biodegradability and an increase in the ratio reflects biodegradability improvement. The marine bacteria Vibrio fischeri was often used to assay the toxicity evolvement of the FQs during degradation process (Vasconcelos et al, 2009;Ge et al, 2010). In this study, the biodegradability and toxicity of ENR after the CWAO process have been investigated by the ratio of BOD 5 /COD and inhibition of the bioluminescence of the marine bacteria V. fischeri.…”

Section: Biodegradability and Toxicity Of Reaction Mixture By Cwaomentioning

confidence: 99%

See 1 more Smart Citation