Photo-degradation of curcumin in the presence of TiO2 nanoparticles: Fundamentals and application

Singh, Umang; Verma, Sandeep; Ghosh, Hirendra N.; Rath, M.C.; Priyadarsini, K. Indira; Sharma, Arun; Pushpa, K. K.; Sarkar, S.K.; Mukherjee, Tulsi

doi:10.1016/j.molcata.2009.11.018

Cited by 37 publications

(11 citation statements)

References 17 publications

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“…The absorption spectra of 1 showed a decrease in the intensity at λ =460 and 435 nm upon light exposure with concomitant increase at λ =385 nm and the appearance of a band at λ =400 nm (see Figure S8d). These bands are assignable to curcumin and its degraded products 13. The experiments in 10 % DMSO/DPBS showed a rapid loss of the emission and absorption intensity (initial rate of photodegradation, k photo =2.8×10 −6 min −1 ) upon photoexposure for 10 minutes ( λ =400–700 nm), owing to the instability of the released curcumin at pH 7.2 (see Figure S9).…”

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confidence: 95%

The cis‐Diammineplatinum(II) Complex of Curcumin: A Dual Action DNA Crosslinking and Photochemotherapeutic Agent

et al. 2015

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[Pt(cur)(NH 3 ) 2 ](NO 3 )( 1), ac urcumin-bound cisdiammineplatinum(II) complex, nicknamed Platicur,a s anovel photoactivated chemotherapeutic agent releases photoactive curcumin and an active platinum(II) species upon irradiation with visible light. The hydrolytic instability of free curcumin reduces upon binding to platinum(II). Interactions of 1 with 5'-GMP and ct-DNAi ndicated formation of platinum-bound DNAa dducts upon exposure to visible light (l = 400-700 nm). It showed apoptotic photocytotoxicity in cancer cells (IC 50 % 15 mm), thus forming · OH, while remaining passive in the darkness (IC 50 > 200 mm). Ac omet assaya nd platinum estimation suggest Pt-DNAcrosslink formation. The fluorescence microscopic images showed cytosolic localization of curcumin, thus implying possibility of dual action as ac hemo-and phototherapeutic agent.

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confidence: 95%

The cis‐Diammineplatinum(II) Complex of Curcumin: A Dual Action DNA Crosslinking and Photochemotherapeutic Agent

et al. 2015

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“…Photophysical studies reported the lifetime of triplet excited state of curcumin to be in microseconds, suggesting that the degradation may proceed very fast and compete with singlet oxygen formation. The photodegradation is accelerated in presence of TiO 2 nanoparticles, and this method can be employed to remove turmeric stains from cotton fabrics [48].…”

Section: Curcumin Reactivitymentioning

confidence: 99%

The Chemistry of Curcumin: From Extraction to Therapeutic Agent

2014

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Curcumin, a pigment from turmeric, is one of the very few promising natural products that has been extensively investigated by researchers from both the biological and chemical point of view. While there are several reviews on the biological and pharmacological effects of curcumin, chemistry reviews are comparatively scarcer. In this article, an overview of different aspects of the unique chemistry research on curcumin will be discussed. These include methods for the extraction from turmeric, laboratory synthesis methods, chemical and photochemical degradation and the chemistry behind its metabolism. Additionally other chemical reactions that have biological relevance like nucleophilic addition reactions, and metal chelation will be discussed. Recent advances in the preparation of new curcumin nanoconjugates with metal and metal oxide nanoparticles will also be mentioned. Directions for future investigations to be undertaken in the chemistry of curcumin have also been suggested.

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“…Titania nanoparticle (TNP) is a widely used nanomaterial; cosmetics and sunscreen products alone account for 50% of TNP usage [3]. Because they are an n-type semiconductor [4], TNPs are also used as a photocell coating and as a photo-catalyst to reduce waterborne or airborne pollutants such as organic dyes, nitric oxide, organophosphorus insecticides, formaldehyde, and benzene [3,5,6]. TNPs have been added to selfcleaning sanitary ceramics, antimicrobial plastic packaging, and cement.…”

Section: Introductionmentioning

confidence: 99%