Photo-cured pH-responsive polyampholyte-coated membranes for controlled release of drugs with different molecular weights and charges

Photo-irradiation paradigm: Mapping a remarkable facile technique used for advanced drug, gene and cell delivery

“…They revealed that the release was significantly correlated to the drug's Mwt (negative relation between the drug's Mwt and release rate) and pH controlled release was not observed in high Mwt drugs as that with low Mwt [107]. In another study conducted by them poly(2-hydroxyethyl methacrylate) membranes were prepared and coated with poly(acrylic acid) using the same formulation technique [109].…”

“…Their results revealed that drug release through those membranes depended to a large extent on the electrostatic interaction between the encapsulated drug and the predominant functional group within the photocrosslinked layer [109].…”

Synthesis and Evaluation of an Organometallic pH-Responsive Nanocomposite

“…Owing to their potential application in the fields of controlled drug delivery, [12][13][14] chemical separation, [15][16][17] chemical valve, [18,19] and so on, these smart membranes have drawn much attention in recent years.…”

“…[23] Ng et al employed photocuring technique of synthesizing pH-responsive membranes using polyampholyte membranes coated with poly(acrylic) acid for the controlled release of drugs with different molecular weight and charges. [14] Kang et al combined two properties by copolymerization with acrylic acid and N-isopropylacrylamide to prepare pH/temperature-sensitive membranes using plasma polymerization technique. The copolymer-blended membranes exhibited both pH-dependent and temperature-sensitive permeability to the aqueous solutions.…”

Preparation of pH-responsive ceramic composite membranes by grafting acrylic acid onto α-alumina membranes

“…As a result, the permeation can be controlled and the selectivity is improved [1] . Therefore, these membranes have great potential applications in drug delivery [2] , chemical separations [3] , chemical valve [4] and etc. So far, several methods such as plasma-induced graft polymerization [5] , photo graft polymerization [6] , self-assembly [7] and chemical graft polymerization [8] have been developed to prepare the pH-responsive membrane by grafting acrylic acid or its derivatives onto the porous membrane surface.…”