Photo-cured hyaluronic acid-based hydrogels containing simvastatin as a bone tissue regeneration scaffold

Bae, Min Soo; Yang, Dae Hyeok; Lee, Jung Bok; Heo, Dong Nyoung; Kwon, Yong‐Dae; Youn, In Chan; Choi, Kuiwon; Hong, Jong Hyun; Kim, Gye Tae; Choi, Yong Suk; Hwang, Eui-Hwan; Kwon, Il Keun

doi:10.1016/j.biomaterials.2011.07.045

Cited by 126 publications

(96 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Generally, natural polymers are modified by the introduction of methacrylate groups on the backbone to yield photopolymerizable materials. Examples include photocrosslinkable natural polymers like gelatin [76,90], hyaluronic acid [5], alginate [45], chitosan [114] and silk fibroin [107]. These materials are explored in stereolithography manly to produce hydrogel scaffolds with and without encapsulated cells.…”

Section: Natural Polymers and Hydrogelsmentioning

confidence: 98%

Photocrosslinkable Materials for the Fabrication of Tissue-Engineered Constructs by Stereolithography

Pereira

Bartolo

2014

Tissue Engineering

View full text Add to dashboard Cite

Stereolithography is an additive technique that produces three-dimensional (3D) solid objects using a multi-layer procedure through the selective photoinitiated curing reaction of a liquid photosensitive material. Stereolithographic processes have been widely employed in Tissue Engineering for the fabrication of temporary constructs, using natural and synthetic polymers, and polymer-ceramic composites. These processes allow the fabrication of complex structures with a high accuracy and precision at physiological temperatures, incorporating cells and growth factors without significant damage or denaturation. Despite recent advances on the development of novel biomaterials and biocompatible crosslinking agents, the main limitation of these techniques are the lack number of available photocrosslinkable materials, exhibiting appropriate biocompatibility and biodegradability. This chapter gives an overview of the current state-of-art of materials and stereolithographic techniques to produce constructs for tissue regeneration, outlining challenges for future research.

show abstract

Section: Natural Polymers and Hydrogelsmentioning

confidence: 98%

Photocrosslinkable Materials for the Fabrication of Tissue-Engineered Constructs by Stereolithography

Pereira

Bartolo

2014

Tissue Engineering

View full text Add to dashboard Cite

show abstract

“…Improve viscoelastic properties and the addition of SIM improved osteogenesis in vitro, although the results were not as notable in vivo [140,141]. Osteoinductive and angiogenic factors can have a synergistic effect on bone mineralization [142][143][144].…”

Section: Hyaluronic Acid Hydrogels Added With Simvastatinmentioning

confidence: 99%

Bone Graft Substitutes for Bone Defect Regeneration. A Collective Review

Kheirallah¹,

Almeshaly²

2016

IJDOS

View full text Add to dashboard Cite

Objective: The purpose of this review article is to illustrate the current state of development of bone graft substitutes that could be used for bone defect regeneration, as well as to analyze their efficacy for clinical use. Methods: An electronic search of the PubMed, was performed for articles written in English. The focused question was "ideal graft substitute material to choose in clinical practice"?. The searches were limited to articles including: bone graft, bone defect scaffold, bone substitutes, and bone regeneration. An attempt was made to identify clinical studies. During the data collection, the data were extracted from the studies including scaffold material, properties and advantages of bone substitutes, as well as clinical results if the study has been provided clinically. Results: In spite of several acceptable scaffold options available for bone regeneration, these options still need to bridge the gap between research and clinical practice. There is little information available about the cellular basis for bone regeneration in humans. Several problems limit the broad usage of such options, including lack of randomized controlled human studies, and dubious long term results. Conclusion:The studies should be nurtured and monitored by a combination of clinical experience. Future trends may focus on the effective combinations of osteoinductive materials, osteoinductive growth factors and cell-based tissue regeneration tactics using composite carriers. There is no single ideal graft material to choose in clinical practice, therefore researches are ongoing in all relevant fields, to establish modern bone regeneration protocols that may lead to the innovation of ideal graft substitutes.

show abstract

“…92 The versatility and biocompatibility of HA has attracted attention for the delivery of growth factors and other biological molecules in tissue engineering scaffolds. 18 Recent approaches have included the delivery of signaling molecules, such as simvastatin, 80 vascular endothelial growth factor, 79,84 platelet-derived growth factor, 84 transforming growth factor beta-1 (TGF-b1), 77 TGF-b3, 76 bone morphogenetic protein-2 (BMP-2), 79 phosphatidylserine, 78 and fibronectin. 85 Bae et al 80 fabricated HA hydrogels loaded with simvastatin prior to photocrosslinking to entrap the molecule within the entangled gel matrix.…”

Section: Hyaluronic Acidmentioning

confidence: 99%

Leveraging “Raw Materials” as Building Blocks and Bioactive Signals in Regenerative Medicine

Renth

Detamore

2012

Tissue Engineering Part B: Reviews

View full text Add to dashboard Cite

Photo-cured hyaluronic acid-based hydrogels containing simvastatin as a bone tissue regeneration scaffold

Cited by 126 publications

References 28 publications

Photocrosslinkable Materials for the Fabrication of Tissue-Engineered Constructs by Stereolithography

Photocrosslinkable Materials for the Fabrication of Tissue-Engineered Constructs by Stereolithography

Bone Graft Substitutes for Bone Defect Regeneration. A Collective Review

Leveraging “Raw Materials” as Building Blocks and Bioactive Signals in Regenerative Medicine

Contact Info

Product

Resources

About