Photo-controlled liquid metal nanoparticle-enzyme for starvation/photothermal therapy of tumor by win-win cooperation

Hu, Jingjing; Liu, Miao‐Deng; Gao, Fan; Chen, Ying; Peng, Song; Li, Duo; Cheng, Han; Zhang, Xian‐Zheng

doi:10.1016/j.biomaterials.2019.119303

Cited by 133 publications

(64 citation statements)

References 30 publications

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“…Such phenomenon has been recently exploited for the fabrication of a variety of novel 2D materials based on interfacial reactions for the application in microfluidics [ 22 ], wearable devices [ 23 ] and self-repairing flexible electronics [ 24 , 25 ], etc. More importantly, by sonication, microchannels or grinding protocols [ [26] , [27] , [28] ], LM nanoparticles (NPs), which possessing own advantages as compared with bulky form, could be prepared and have found such diverse applications in antitumor therapy [ 29 , 30 ], antibacterial [ 31 ], soft electronics [ 32 ] and thermal management field [ 33 ]. Putting the above-mentioned properties together, i.e.…”

Section: Introductionmentioning

confidence: 99%

Galvanic replacement reaction for in situ fabrication of litchi-shaped heterogeneous liquid metal-Au nano-composite for radio-photothermal cancer therapy

Guo

Wang

et al. 2021

Bioactive Materials

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With tremendous research advances in biomedical application, liquid metals (LM) also offer fantastic chemistry for synthesis of novel nano-composites. Herein, as a pioneering trial, litchi-shaped heterogeneous eutectic gallium indium-Au nanoparticles (EGaIn-Au NPs), served as effective radiosensitizer and photothermal agent for radio-photothermal cancer therapy, have been successfully prepared using in situ interfacial galvanic replacement reaction. The enhanced photothermal conversion efficiency and boosted radio-sensitization effect could be achieved with the reduction of Au nanodots onto the eutectic gallium indium (EGaIn) NPs surface. Most importantly, the growth of tumor could be effectively inhibited under the combined radio-photothermal therapy mediated by EGaIn-Au NPs. Inspired by this approach, in situ interfacial galvanic replacement reaction may open a novel strategy to fabricate LM-based nano-composite with advanced multi-functionalities.

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Section: Introductionmentioning

confidence: 99%

Galvanic replacement reaction for in situ fabrication of litchi-shaped heterogeneous liquid metal-Au nano-composite for radio-photothermal cancer therapy

Guo

Wang

et al. 2021

Bioactive Materials

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“…Similar to most nanoparticles, these LMNPs showed accumulation in liver and spleen. [ 49 ] A small amount was detected in lung, while an obvious clearance after about 72 h was detected. [ 50 ] The chemical engineering methods on the surfaces as well as the size difference would influence the biodistribution.…”

Section: Advantages Of Lmnp In Biomedicinementioning

confidence: 99%

“…Attributed to the unique soft core, favorable biocompatibility, and multiply stimuli‐responsive features, LMNPs have emerged as promising candidates in tumor treatments, which includes hyperthermia, elevated ROS, enhanced endosome escape, tumor starvation, and the synergetic therapies among them. [ 49,64 ] Thermal physiotherapy benefits a lot from its advantages of minimal invasion, reduced chance of infection, and obvious therapeutic performance. [ 112 ] The advancement of nanotechnology has greatly advanced the field, attributed to the physical, chemical, and biological virtues, which enables controllable heat production and transfer, conformable ablation regulation, and the allied advantages of drug delivery and the imaging capability.…”

Section: Applications Of Lmnps In Biomedicinementioning

confidence: 99%

Nano‐Biomedicine based on Liquid Metal Particles and Allied Materials

Sun

Yuan

Wang

et al. 2021

Advanced NanoBiomed Research

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Liquid metals (LMs) have emerged as a new class of functional materials with attractive characteristics of low melting points and metal properties. Remarkable features, such as biocompatibility, injectability, plasticity, conductivity, and shape transformability, have rendered them as excellent candidates to tackle challenging biomedical issues, such as tumor clinics, tissue engineering, and even nerve connection. Scaling down the droplet size offers more opportunities in surface engineering and functionalization, thus providing broad biomedical scenarios expanding from drug delivery, enhanced bioheat transfer, tumor therapeutics, and bioelectronics to nanorobots. Despite in its infancy stage, a summary about the advancement of LM biomedical nanomaterials is urgently needed. This review aims to highlight the advantages of gallium‐based LM nanoparticles enabled nano‐biomedicine, to summarize the recent synthesis methods with diverse LM compositions, structures and surface modifications, and to introduce their typical state‐of‐the‐art biomedical applications. Challenges and opportunities are also discussed in the end.

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“…Till now, studies have shown several preliminary evidences of LMs as biocompatible bioelectrodes, nanomaterials, or drug car riers. [45][46][47] However, for such an implantable materials, the bio logical toxicity could not be ignored. So we designed in vitro and in vivo experiments to systematically evaluate the biotox icity of GMs.…”

Section: Biocompatible Evaluation Of Gmsmentioning

confidence: 99%

Liquid Metal Microparticles Phase Change Medicated Mechanical Destruction for Enhanced Tumor Cryoablation and Dual‐Mode Imaging

Sun

Cui

Yuan

et al. 2020

Adv Funct Materials

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Mechanical forces are crucial for normal living organisms as well as formation of tumor microenvironments. However, to date, there are rather limited trials to regulate the mechanical factors toward tumor treatment or imaging. Here, a synergistic antitumor therapy of cryoablation and gallium microparticles (GMs) mediated bomb-explosion-like mechanical destruction is proposed for the first time. Moreover, the GMs are demonstrated to enhance the T2 magnetic resonance imaging (MRI) effect and mediate the dual-mode imaging of computerized tomography (CT) and MRI. The GMs are found to exert a mechanical force to surrounding chitosan ice crystals during freezing, which is attributed to the volume expansion during the phase transition process. Meanwhile, the phenomenon of piercing gallium materials via a sword-like shape into the solid ice crystals is observed with a penetration length of 150 µm within 1 ms, which further shows the remarkable mechanical destruction to frozen ice crystals. Furthermore, a series of in vitro and in vivo results prove the negligible biotoxicity and good biocompatible of GMs. The in vivo synergistic therapy exhibits effective destructive results with reduced recurrence rate and prolonged survival. The present methods are expected to not only open an efficient tumor destructive approach, but also hold potential for advanced theranostic systems.

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Photo-controlled liquid metal nanoparticle-enzyme for starvation/photothermal therapy of tumor by win-win cooperation

Cited by 133 publications

References 30 publications

Galvanic replacement reaction for in situ fabrication of litchi-shaped heterogeneous liquid metal-Au nano-composite for radio-photothermal cancer therapy

Galvanic replacement reaction for in situ fabrication of litchi-shaped heterogeneous liquid metal-Au nano-composite for radio-photothermal cancer therapy

Nano‐Biomedicine based on Liquid Metal Particles and Allied Materials

Liquid Metal Microparticles Phase Change Medicated Mechanical Destruction for Enhanced Tumor Cryoablation and Dual‐Mode Imaging

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