Photo-bio-synthesis of irregular shaped functionalized gold nanoparticles using edible mushroom Pleurotus florida and its anticancer evaluation

Ravishankar, B; Sharanabasava, V. Ganachari; Deshpande, Raghunandan; Shetti, Ullas N; Sanjeev, Ganesh; Venkataraman, A.

doi:10.1016/j.jphotobiol.2013.05.002

Cited by 120 publications

(53 citation statements)

References 17 publications

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“…The area-profile study of the Ag-NPs exhibited strong peaks of Ag at 2.5 keV that are specific of Ag-NPs, combined by Cl and O signals by underneath 1 keV. EDXA study exhibited that CI and O signatures were the results of X-ray release by proteins attached with the AgNPs outer region, and then, the boundless particles were separated by centrifugation followed by constant cleaning [17,18].…”

Section: Resultsmentioning

confidence: 99%

Seagrass-mediated silver nanoparticles synthesis by Enhalus acoroides and its α-glucosidase inhibitory activity from the Gulf of Mannar

Senthilkumar¹,

Kumar²,

Sudhagar³

et al. 2016

J Nanostruct Chem

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Enhalus acoroides (Linnaeus f.) Royle belongs to the Family: Hydrocharitaceae is an abundantly growing seagrass in coastal areas of Gulf of Mannar. Sea grasses contain very good potent therapeutic properties for challenging diseases. The current investigation is to green synthesis Ag-NPs from Enhalus acoroides and characterize silver nanoparticles (Ag-NPs) and evaluated a-glucosidase inhibition activity. Furthermore, the characterization of the same using ultraviolet-visible spectroscopy (UV-Vis), Fourier transform infrared (FT-IR) spectroscopy, X-ray diffraction (XRD), energy dispersive X-ray (EDX), and followed by Transmission Electron Microscopy (TEM). Surface Plasmon resonance exhibited the development of Ag-NPs in UV-Visible spectra at 419 nm. The FTIR examination was done to find and read the moiety accountable aimed at the bioconversion of silver ions. The crystalline form was observed in the XRD examination. The synthesized Ag-NPs were polydispersed spherical AgNPs as confirmed by EDAX and stabilized in the solution with the spherical shapes further confirmed by TEM analysis designate in the reading of 2-100 nm. The findings of the study shown that Ag-NPs of promisingly proved have strong a-glucosidase inhibitory activity by which AgNPs with an IC 50 47 lg/ml. This current research report is first to account on the green synthesis of silver nanoparticles from seagrass E. acoroides, because there is no literature survey and investigations on Enhalus acoroides. Hence, we suggest that Ag-NPs synthesized from E. acoroides might be a significant resource of a-glucosidase inhibitors preparation that may benefit diabetes treatment.

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Section: Resultsmentioning

confidence: 99%

Seagrass-mediated silver nanoparticles synthesis by Enhalus acoroides and its α-glucosidase inhibitory activity from the Gulf of Mannar

Senthilkumar¹,

Kumar²,

Sudhagar³

et al. 2016

J Nanostruct Chem

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“…24,25 In an earlier study, the formation of the AuNPs was obtained under light conditions within 12 hours. 26 This indicated that the formation of AuNPs depends on the condition, concentration of the mushroom extracts, and also the incubation time.…”

Section: Results and Discussion Extracellular Mycosynthesis Of Aunpsmentioning

confidence: 98%

Neurite outgrowth stimulatory effects of mycosynthesized AuNPs from Hericium erinaceus (Bull.: Fr.) Pers. on pheochromocytoma (PC-12) cells

Raman¹,

Lakshmanan²,

John³

et al. 2015

IJN

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Background Hericium erinaceus has been reported to have a wide range of medicinal properties such as stimulation of neurite outgrowth, promotion of functional recovery of axonotmetic peroneal nerve injury, antioxidant, antihypertensive, and antidiabetic properties. In recent years, the green synthesis of gold nanoparticles (AuNPs) has attracted intense interest due to the potential use in biomedical applications. The aim of this study was to investigate the effects of AuNPs from aqueous extract of H. erinaceus on neurite outgrowth of rat pheochromocytoma (PC-12) cells. Methods The formation of AuNPs was characterized by UV–visible spectrum, energy dispersive X-ray (EDX), field-emission scanning electron microscope (FESEM), transmission electron microscopy (TEM), particle size distribution, and Fourier transform-infrared spectroscopy (FTIR). Furthermore, the neurite extension study of synthesized AuNPs was evaluated by in vitro assay. Results The AuNPs exhibited maximum absorbance between 510 and 600 nm in UV–visible spectrum. FESEM and TEM images showed the existence of nanoparticles with sizes of 20–40 nm. FTIR measurements were carried out to identify the possible biomolecules responsible for capping and efficient stabilization of the nanoparticles. The purity and the crystalline properties were confirmed by EDX diffraction analysis, which showed strong signals with energy peaks in the range of 2–2.4 keV, indicating the existence of gold atoms. The synthesized AuNPs showed significant neurite extension on PC-12 cells. Nerve growth factor 50 ng/mL was used as a positive control. Treatment with different concentrations (nanograms) of AuNPs resulted in neuronal differentiation and neuronal elongation. AuNPs induced maximum neurite outgrowth of 13% at 600 ng/mL concentration. Conclusion In this study, the AuNPs synthesis was achieved by a simple, low-cost, and rapid bioreduction approach. AuNPs were shown to have potential neuronal differentiation and stimulated neurite outgrowth. The water-soluble bioconstituents could be responsible for the neuroactivity. This is the first report for the biosynthesis of AuNPs using the hot aqueous extract of H. erinaceus .

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“…Application of mushrooms of the Pleurotus genus for nanoparticle synthesis is one of the major approaches of green chemistry [7,8]. Thus, the authors of [9] shows an environmentally friendly, non-toxic and cost-effective way to obtain gold nanoparticles from aqueous medium by using the culture filtrate of the mushrooms Pleurotus sapidus as condensing and stabilizing agent.…”

Section: Introductionmentioning

confidence: 99%

“…The last has been driven by a unique combination of physicochemical and biological properties of these nanoparticles. The authors of [7] using an extract of mushroom Pleurotus florida under the influence of solar energy obtained gold nanoparticles, which possess anti-cancer properties in relation to different cancer cell lines A-549 (Human lung carcinoma), K-562 (Human chronic myelogenous leukemia bone marrow), Hela (Human cervix) and MDA-MB (Human adenocarcinoma mammary gland). Moreover, no lethal effect was found in studies in Vero for monkey kidney cells Chlorocebus aethiops (Green monkey).…”

Section: Introductionmentioning

confidence: 99%

Zirconia Nanoparticles Impact On Morphophysiological Data And Mineral Composition Of P. ostreatus

Doroshkevich

Frontasyeva

Doroshkevich

et al. 2015

Ecological Chemistry and Engineering S

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Neutron activation analysis of the Pleurotus ostreatus showed that adding of solid solution of ZrO2-Y2O3 hydroxide and oxide (3 mol % Y2O3) nanoparticles of size 4 and 9 nm at a concentration of 0.2 weight percent in a nutrient medium (Czapek) alters the character of physiological processes in the biological tissues of the mushrooms. This is manifested in the form of a significant change in morphological and physiological characteristics of the mushrooms and the elemental composition of the dry biomass. In particular, it is shown that the intercalation of nanoparticles into the tissues of the mushrooms leads to an increase of 1.3-1.4 times (more than 2.6 g/dm 3 ) of biomass accumulation (industrial strain HK 35) and decrease of 1.7-1.8 times (below 1.7-2.5 mg/mm 3 ) of concentrations of extracellular proteins into the culture fluid at a substantially constant value of the acidity. It is shown that the addition of ZrO2+3 mol % Y2O3 nanoparticles of sizes 4 or 9 nm into tissue of mushroom at step of the mother mycelium in very small concentrations can alter effectively the chemical composition of the substances produced by the cells and consequently, its physiological activity. It is shown that the use of low concentrations of ZrO2 nanoparticles allow to increase the yield and resistance of crops to diseases up to 1.2-1.5 times, as well as in the long term can be used in biomedical technologies for the treatment of cancer diseases.

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Photo-bio-synthesis of irregular shaped functionalized gold nanoparticles using edible mushroom Pleurotus florida and its anticancer evaluation

Cited by 120 publications

References 17 publications

Seagrass-mediated silver nanoparticles synthesis by Enhalus acoroides and its α-glucosidase inhibitory activity from the Gulf of Mannar

Seagrass-mediated silver nanoparticles synthesis by Enhalus acoroides and its α-glucosidase inhibitory activity from the Gulf of Mannar

Neurite outgrowth stimulatory effects of mycosynthesized AuNPs from Hericium erinaceus (Bull.: Fr.) Pers. on pheochromocytoma (PC-12) cells

Zirconia Nanoparticles Impact On Morphophysiological Data And Mineral Composition Of P. ostreatus

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Photo-bio-synthesis of irregular shaped functionalized gold nanoparticles using edible mushroom Pleurotus florida and its anticancer evaluation

Cited by 120 publications

References 17 publications

Seagrass-mediated silver nanoparticles synthesis by Enhalus acoroides and its α-glucosidase inhibitory activity from the Gulf of Mannar

Seagrass-mediated silver nanoparticles synthesis by Enhalus acoroides and its α-glucosidase inhibitory activity from the Gulf of Mannar

Neurite outgrowth stimulatory effects of myco&shy;synthesized AuNPs from Hericium erinaceus (Bull.: Fr.) Pers. on pheochromocytoma (PC-12) cells

Zirconia Nanoparticles Impact On Morphophysiological Data And Mineral Composition Of P. ostreatus

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Neurite outgrowth stimulatory effects of mycosynthesized AuNPs from Hericium erinaceus (Bull.: Fr.) Pers. on pheochromocytoma (PC-12) cells