Photo- and thermo-responsive microgels with supramolecular crosslinks for wavelength tunability of the volume phase transition temperature

Liang, Wenjing; Lopez, Carlos G.; Richtering, Walter; Wöll, Dominik

doi:10.1039/d2cp00532h

Cited by 6 publications

(5 citation statements)

References 64 publications

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“…Localization densities are calculated based on a constant bin volume (9 × 10 6 nm 3 ) and a logistic curve fit is conducted to quantify the distribution (see the Supporting Information). The comparison of these two diagrams suggests that our generated microgels are statistically consistent with the real ones, indicating that our model successfully captures the structural properties of the microgels. Moreover, the similarity between the radial distributions at different temperatures suggests that our model is capable of accurately modeling the dependence of microgel structure on temperature.…”

supporting

confidence: 58%

Modeling the Temperature-Dependent Size Change of Polydisperse Nano-objects using a Deep Generative Model

Azad,

Lenßen,

Jia

et al. 2024

Nano Lett.

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Modern microscopy techniques can be used to investigate soft nano-objects at the nanometer scale. However, timeconsuming microscopy measurements combined with low numbers of observable polydisperse objects often limit the statistics. We propose a method for identifying the most representative objects from their respective point clouds. These point cloud data are obtained, for example, through the localization of single emitters in super-resolution fluorescence microscopy. External stimuli, such as temperature, can cause changes in the shape and properties of adaptive objects. Due to the demanding and time-consuming nature of super-resolution microscopy experiments, only a limited number of temperature steps can be performed. Therefore, we propose a deep generative model that learns the underlying point distribution of temperature-dependent microgels, enabling the reliable generation of unlimited samples with an arbitrary number of localizations. Our method greatly cuts down the data collection effort across diverse experimental conditions, proving invaluable for soft condensed matter studies.

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supporting

confidence: 58%

Modeling the Temperature-Dependent Size Change of Polydisperse Nano-objects using a Deep Generative Model

Azad,

Lenßen,

Jia

et al. 2024

Nano Lett.

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“…Natural macromolecules include hyaluronic acid, [ 115 ] chitosan, [ 116 ] agar, [ 117 ] gelatin, [ 118 ] etc. Common synthetic polymers include poly (n‐isopropylacrylamide) (PNIPAAm), [ 119,120 ] polyethylene glycol (PEG), [ 121 ] poly (ethylene) (PCL). [ 122 ] PTAs for photothermal hydrogels can be divided into inorganic materials and organic materials according to the different sources.…”

Section: The Classification Of Pchsmentioning

confidence: 99%

Photo‐Controllable Smart Hydrogels for Biomedical Application: A Review

Zhao,

Ran,

Lee

et al. 2023

Small Methods

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Nowadays, smart hydrogels are being widely studied by researchers because of their advantages such as simple preparation, stable performance, response to external stimuli, and easy control of response behavior. Photo‐controllable smart hydrogels (PCHs) are a class of responsive hydrogels whose physical and chemical properties can be changed when stimulated by light at specific wavelengths. Since the light source is safe, clean, simple to operate, and easy to control, PCHs have broad application prospects in the biomedical field. Therefore, this review timely summarizes the latest progress in the PCHs field, with an emphasis on the design principles of typical PCHs and their multiple biomedical applications in tissue regeneration, tumor therapy, antibacterial therapy, diseases diagnosis and monitoring, etc. Meanwhile, the challenges and perspectives of widespread practical implementation of PCHs are presented in biomedical applications. This study hopes that PCHs will flourish in the biomedical field and this review will provide useful information for interested researchers.

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“…Photosensitive swelling has been reported by photoisomerization of substituents like azo groups or spiropyranes, which change their polarity upon photoisomerization, but also by light-induced splitting of a fraction of the crosslinks. 16,17 Particularly, photosensitive nitrobenzyl groups have been described either to protect a crosslinking group (cageing) or for degradation of crosslinks. 15,[18][19][20][21][22] For example, Landfester et al prepared photodegradable PMMA microgels using bis(methacryloyl) crosslinkers with o-nitrobenzyl groups, which could be selectively addressed by adjusting the wavelength and irradiation time.…”

Section: Introductionmentioning

confidence: 99%

Photocrosslinked and pH-switchable Soft Polymer Nanocapsules from Polyglycidyl Ethers

Engel,

Jeschenko,

van Dongen

et al. 2023

Preprint

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Soft polymer nanocapsules and microgels, which can adapt their shape and at the same time sequester and release molecular payloads in response to an external trigger, are a challenging complement to vesicular structures like polymersomes. In this work we report the synthesis of such capsules by photocrosslinking of coumarin-substituted polyglycidyl ethers, which we prepared by Williamson etherification of epichlorohydrin (ECH) repeating units with 7-hydroxycoumarin in copolymers with tert-butyl glycidyl ether (tBGE). To control capsule size, we employed the prepolymers in an o/w miniemulsion, where they formed a gel layer at the interface upon irradiation at 365 nm by [2π+2π] photodimerization of the coumarin groups. Upon irradiation at 245 nm, the reaction could be reversed and the gel wall could be repeatedly disintegrated and rebuilt. We further demonstrated (i) reversible hydrophilization of the gels by hydrolysis of the lactone rings in coumarin dimers as a mechanism to manipulate the permeability of the capsules, and (ii) binding functional molecules as amides. Together with the possibility to hydrolyze the tert-butyl ether group we demonstrate a remarkable versatility of such nanogels for their use as a carrier system.

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Photo- and thermo-responsive microgels with supramolecular crosslinks for wavelength tunability of the volume phase transition temperature

Abstract: Microgels with photoswitchable crosslinkers based on trans azobenzene−β-cyclodextrin interaction enable irradiation wavelength-dependent control over the microgel swelling capacity and the volume phase transition temperature.

Cited by 6 publications

References 64 publications

Modeling the Temperature-Dependent Size Change of Polydisperse Nano-objects using a Deep Generative Model

Modeling the Temperature-Dependent Size Change of Polydisperse Nano-objects using a Deep Generative Model

Photo‐Controllable Smart Hydrogels for Biomedical Application: A Review

Photocrosslinked and pH-switchable Soft Polymer Nanocapsules from Polyglycidyl Ethers

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