Photo- and Radiofrequency-Induced Heating of Photoluminescent Colloidal Carbon Dots

Mussabek, Gauhar; Zhylkybayeva, Nazym; Lysenko, Ivan; Lishchuk, Pavlo; Baktygerey, Saule; Yermukhamed, Dana; Taurbayev, Yerzhan; Sadykov, Gani; Zaderko, Alexander N.; Skryshevsky, V. A.; Lisnyak, Vladyslav V.; Lysenko, V.

doi:10.3390/nano12142426

Cited by 6 publications

(5 citation statements)

References 56 publications

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“…The total content of oxygen-containing groups is 68.8% by weight. Some properties and composition of such particles were previously investigated in [ 20 ].…”

Section: Resultsmentioning

confidence: 99%

In vitro and in vivo toxicity of carbon dots with different chemical compositions

Kuznietsova,

Géloën,

Dziubenko

et al. 2023

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Carbon dots (CDs) are easy-obtained nanoparticles with wide range of biological activity; however, their toxicity after prolonged exposure is poorly investigated. So, in vitro and in vivo toxicity of CDs with the surfaces enriched with hydroxylated hydrocarbon chains and methylene groups (CD_GE), carboxyl and phenol groups accompanied with nitrogen (CD_3011), trifluoromethyl (CDF19) or toluidine and aniline groups (CDN19) were aimed to be discovered. CDs’ in vitro toxicity was assessed on A549 cells (real-time cell analysis of impedance, fluorescence microscopy) after 24 h of incubation, and we observed no changes in cell viability and morphology. CDs’ in vivo toxicity was assessed on C57Bl6 mice after multiple dosages (5 mg/kg subcutaneously) for 14 days. Lethality (up to 50%) was observed in CDN19 and CD_3011 groups on different days of dosing, accompanied by toxicity signs in case of CD_3011. There were no changes in serum biochemical parameters except Urea (increased in CDF19 and CD_3011 groups), nor substantial kidney, liver, and spleen injuries. The most impactful for all organs were also CD_3011 and CDF19, causing renal tubule injury and liver blood supply violation. Thus, CDs with a surface enriched with oxygen- and nitrogen-containing functional groups might be toxic after multiple everyday dosing, without, however, significant damages of internal organs in survived animals.

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“…The total content of oxygen-containing groups is 68.8% by weight. Some properties and composition of such particles were previously investigated in [ 20 ].…”

Section: Resultsmentioning

confidence: 99%

In vitro and in vivo toxicity of carbon dots with different chemical compositions

Kuznietsova,

Géloën,

Dziubenko

et al. 2023

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“…Carbon dots used in this study were prepared by solvothermal carbonization of a mixture of urea and anhydrous citric acid, taken in a molar ratio of 2:1. CD preparation and characterization was described in detail in (Kuznietsova, et al, 2023b;Mussabek, et al, 2022;Ivanov, et al, 2021;Dubyk, et al, 2022). CD dressing was prepared by mixing CD solution in a saline (1 mg/mL) with commercially available hydrogel Hydrosorb Gel (Hartmann, Germany) that consisted of Ringer solution, carboxyethyl-and carboxymethyl-cellulose, in a 1:1 ratio.…”

Section: Methodsmentioning

confidence: 99%

Carbon dot dressing as a treatment of alkali-induced skin burns

Kuznietsova,

Ishchuk,

Bogatyryov

et al. 2024

Biol. Stud.

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Background. Chemical burns, comprising 5–10 % of total burns but causing 30 % of burn-related deaths, are now a notable concern in Ukraine. Current clinical protocols lack specific approaches for chemical burns, and research on this type of burn is limited. Carbon-based nanoparticles show promise for wound healing because of anti-inflammatory, antioxidant, and antibacterial activities. So, the ability of carbon dots obtained from citric acid and urea (further called CD) to improve the healing of alkali-induced skin burn was aimed to be discovered. Materials and Methods. The study was conducted on male Wistar rats. Burn was modeled by application of gauze disc soaked with 3 M NaOH solution on shaved skin of anesthetized rats for 10 min. A CD dressing, consisting of a CD solution (1 mg/mL) mixed with cellulose-based hydrogel that served as a vehicle, was applied to burned skin daily during a 7-day period. There were following groups: control (healthy rats), a burn-only group (rats that received no dressing), a burn + vehicle group (rats that received vehicle dressing), and a burn + CD group (rats that received CD dressing). The study involved monitoring of burn areas, conducting skin histopathology, and performing blood biochemical analyses. Results. The daily CD dressing significantly decreased alkali-induced burn area (by 76 % compared to 40 % in burn-only group) after seven daily dressings. The level of inflammation in the burn site was also less expressed in CD-treated animals, compared to respective controls (non-treated animals and animals treated with Vehicle). There was no substantial systemic toxicity of the burn (of such area) and its healing, manifested by absence of body weight loss, and absence of dramatical changes in serum biochemical parameters (indicators of liver and kidney function). However, animals of all the groups that experienced burns had a significantly lower body weight gain and mesenteric lymph nodes weight compared to healthy rats. Conclusions. So, the application of carbon dots mixed with hydrogel speeded up alkali-induced burn healing without negative impact on the organism.

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“…For these reasons, there is a high interest in C-dots, especially in the biomedical field, to be used as drug delivery vehicles, as well as for cell imaging and in vivo bioimaging [ 14 , 15 ]. Moreover, C-dots can be employed for advanced biomedical applications such as hyperthermia and pH sensing, as they often possess temperature- or pH-dependent photoluminescence [ 16 , 17 ].…”

Section: Introductionmentioning

confidence: 99%

Fluorescent Carbon Dots from Food Industry By-Products for Cell Imaging

Mancini

Menichetti

Esposti

et al. 2023

JFB

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Herein, following a circular economy approach, we present the synthesis of luminescent carbon dots via the thermal treatment of chestnut and peanut shells, which are abundant carbon-rich food industry by-products. As-synthesized carbon dots have excellent water dispersibility thanks to their negative surface groups, good luminescence, and photo-stability. The excitation–emission behaviour as well as the surface functionalization of these carbon dots can be tuned by changing the carbon source (chestnuts or peanuts) and the dispersing medium (water or ammonium hydroxide solution). Preliminary in vitro biological data proved that the samples are not cytotoxic to fibroblasts and can act as luminescent probes for cellular imaging. In addition, these carbon dots have a pH-dependent luminescence and may, therefore, serve as cellular pH sensors. This work paves the way towards the development of more sustainable carbon dot production for biomedical applications.

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Photo- and Radiofrequency-Induced Heating of Photoluminescent Colloidal Carbon Dots

Cited by 6 publications

References 56 publications

In vitro and in vivo toxicity of carbon dots with different chemical compositions

In vitro and in vivo toxicity of carbon dots with different chemical compositions

Carbon dot dressing as a treatment of alkali-induced skin burns

Fluorescent Carbon Dots from Food Industry By-Products for Cell Imaging

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