Photo- and pH-responsive drug delivery nanocomposite based on o-nitrobenzyl functionalized upconversion nanoparticles

Wang, Xiaotao; Yang, Yebin; Liu, Chuang; Guo, Haipeng; Chen, Zhuofan; Xia, Junyong; Liao, Yonggui; Tang, Chak Yin; Law, Wing Cheung

doi:10.1016/j.polymer.2021.123961

Cited by 18 publications

(8 citation statements)

References 46 publications

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“…Recently, advances in nanotechnology have shifted the light source to the near-infrared region (650–1000 nm), greatly overcoming the shortcomings of UV light and enabling noninvasive, biocompatible, and precise treatment of deep-tissue diseases. − In the NIR light-controlled drug delivery approach, biophotonic nanomaterials, especially upconversion NPs (UCNPs), are normally used as versatile NIR-to-UV–visible (UV–vis) optical transducers to generate in situ high-intensity light sources for on-demand therapeutic light release with fewer side effects and better tissue penetration. , Therefore, the application of UCNPs in NIR photolysis has received increasing attention. By introducing two electron-donating groups to ONB, the maximum absorption peak is observed at 350 nm, overlapping with the 1 I 6 → 3 F 4 (340 nm) and 1 D 2 → 3 H 6 (360 nm) transitions of Tm 3+ -containing UCNPs. − …”

Section: Introductionmentioning

confidence: 95%

NIR-Cleavable and pH-Responsive Polymeric Yolk–Shell Nanoparticles for Controlled Drug Release

et al. 2023

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Responsive drug release and low toxicity of drug carriers are important for designing controlled release systems. Here, a double functional diffractive o-nitrobenzyl, containing multiple electron-donating groups as a crosslinker and methacrylic acid (MAA) as a monomer, was used to decorate upconversion nanoparticles (UCNPs) to produce robust poly o-nitrobenzyl@UCNP nanocapsules using the distillation-precipitation polymerization and templating method. Poly o-nitrobenzyl@UCNP nanocapsules with a robust yolk–shell structure exhibited near-infrared (NIR) light-/pH-responsive properties. When the nanocapsules were exposed to 980 nm NIR irradiation, the loaded drug was efficiently released by altering the shell of the nanocapsules. The photodegradation kinetics of the poly o-nitrobenzyl@UCNP nanocapsules were studied. The anticancer drug, doxorubicin hydrochloride (DOX), was loaded at pH 8.0 with a loading efficiency of 13.2 wt %. The Baker–Lonsdale model was used to determine the diffusion coefficients under different release conditions to facilitate the design of dual-responsive drug release devices or systems. Additionally, cytotoxicity studies showed that the drug release of DOX could be efficiently triggered by NIR to kill cancer cells in a controlled manner.

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Section: Introductionmentioning

confidence: 95%

NIR-Cleavable and pH-Responsive Polymeric Yolk–Shell Nanoparticles for Controlled Drug Release

et al. 2023

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“…In UCNPs systems, the application of near-infrared light, the generated UV-visible light, and the generated heat are crucial elements in accelerating the response process to various stimuli. Wang et al Synthesized a NIR and pH dual-responsive drug-release nanocapsule [20]. The lanthanide-ion-doped UCNPs cores and convertible poly-o-nitrobenzyl shells.…”

Section: Multiple-responsive Ucnpsmentioning

confidence: 99%

Up-conversion Nanoparticles with Drugs Target the Tumor Microenvironment

Tian

2023

TNS

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The internal environment in which cancer cells develop and persist is referred to as the tumor microenvironment (TME). Cancer cells interact with the microenvironment, leading to further cell proliferation and migration. Traditional Chinese medicines (TCM) have been shown in trials that can target and improve the tumor microenvironment. Up-conversion nanoparticles (UCNPs) can exploit the properties of the tumor microenvironment for precise targeting while preventing the premature release of their loaded medications. In this overview, we review any existing research results on the targeting of tumor microenvironment by Traditional Chinese medicines and Up-conversion nanoparticles in recent years. We discuss the possibilities and advantages of combining Traditional Chinese medicines with Up-conversion nanoparticles and summarize their current unresolved issues.

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“…The advantage of UCNP surface modification is also the possibility of introducing functional groups allowing the attachment of a large number of biomolecules such as peptides, proteins, antibodies, DNAs, drugs, photosensitizers, etc., which facilitate specific targeting and treatment. These functional groups consist of carboxyl, amino, thiol, maleimide, aldehyde, phosphate, bisphosphonate, sulfonate, and even o-nitrobenzyl groups [24]. General surface engineering strategies of UCNPs include ligand oxidation, replacement, or removal of hydrophobic stabilizers, as well as silanization, layer-by-layer assembly, coating with amphiphilic polymers, etc.…”

Section: Introductionmentioning

confidence: 99%

Toxicity of Large and Small Surface-Engineered Upconverting Nanoparticles for In Vitro and In Vivo Bioapplications

Machová Urdzíková,

Mareková,

Vasylyshyn

et al. 2024

IJMS

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In this study, spherical or hexagonal NaYF4:Yb,Er nanoparticles (UCNPs) with sizes of 25 nm (S-UCNPs) and 120 nm (L-UCNPs) were synthesized by high-temperature coprecipitation and subsequently modified with three kinds of polymers. These included poly(ethylene glycol) (PEG) and poly(N,N-dimethylacrylamide-co-2-aminoethylacrylamide) [P(DMA-AEA)] terminated with an alendronate anchoring group, and poly(methyl vinyl ether-co-maleic acid) (PMVEMA). The internalization of nanoparticles by rat mesenchymal stem cells (rMSCs) and C6 cancer cells (rat glial tumor cell line) was visualized by electron microscopy and the cytotoxicity of the UCNPs and their leaches was measured by the real-time proliferation assay. The comet assay was used to determine the oxidative damage of the UCNPs. An in vivo study on mice determined the elimination route and potential accumulation of UCNPs in the body. The results showed that the L- and S-UCNPs were internalized into cells in the lumen of endosomes. The proliferation assay revealed that the L-UCNPs were less toxic than S-UCNPs. The viability of rMSCs incubated with particles decreased in the order S-UCNP@Ale-(PDMA-AEA) > S-UCNP@Ale-PEG > S-UCNPs > S-UCNP@PMVEMA. Similar results were obtained in C6 cells. The oxidative damage measured by the comet assay showed that neat L-UCNPs caused more oxidative damage to rMSCs than all coated UCNPs while no difference was observed in C6 cells. An in vivo study indicated that L-UCNPs were eliminated from the body via the hepatobiliary route; L-UCNP@Ale-PEG particles were almost eliminated from the liver 96 h after intravenous application. Pilot fluorescence imaging confirmed the limited in vivo detection capabilities of the nanoparticles.

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Photo- and pH-responsive drug delivery nanocomposite based on o-nitrobenzyl functionalized upconversion nanoparticles

Cited by 18 publications

References 46 publications

NIR-Cleavable and pH-Responsive Polymeric Yolk–Shell Nanoparticles for Controlled Drug Release

NIR-Cleavable and pH-Responsive Polymeric Yolk–Shell Nanoparticles for Controlled Drug Release

Up-conversion Nanoparticles with Drugs Target the Tumor Microenvironment

Toxicity of Large and Small Surface-Engineered Upconverting Nanoparticles for In Vitro and In Vivo Bioapplications

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