Photo‐affinity and Metabolic Labeling Probes Based on the Opioid Alkaloids
Mark Anthony Leon Duque,
Nandini Vallavoju,
Tiffany Zhang
et al.
Abstract:The opioids are powerful analgesics but carry many contingencies that can lead to opioid‐use disorder. Chemical probes derived from the opioid alkaloids can provide deeper insight into the molecular interactions in a cellular context. Here, we designed and developed photo‐click morphine (PCM‐2) as a photo‐affinity probe based on morphine and dialkynyl‐acetyl morphine (DAAM) as a metabolic acetate reporter based on heroin. Application of these probes to SH‐SY5Y, HEK293T, and U2OS cells revealed that PCM‐2 and D… Show more
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