Photo-activated synthesis and characterization of gold nanoparticles from Punica granatum L. seed oil: An assessment on antioxidant and anticancer properties for functional yoghurt nutraceuticals

Lydia, D. Esther; Khusro, Ameer; Immanuel, P.; Esmail, Galal Ali; Al-Dhabi, Naïf Abdullah; Arasu, Mariadhas Valan

doi:10.1016/j.jphotobiol.2020.111868

Cited by 37 publications

(10 citation statements)

References 19 publications

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“…The synthesized nanoparticles have the ability to inhibit the growth of cell lines HeLa and DlD1. The anticancer activity of nanoparticles has been reported previously (Valsalam et al, 2019;Venkatadri et al, 2020;Lydia et al, 2020;Malar et al, 2020).…”

Section: Anticancer Activity Of Iron Npsmentioning

confidence: 85%

Green synthesis of iron nanoparticles using aqueous extract of Turbinaria conoides (J. Agardh) and their anticancer properties

Bensy

Christobel

2021

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Marine macroalgae produce numerous bioactive compounds with potential pharmacological properties. In this study, macroalga was collected from the Gulf of Mannar, India and identified as, Turbinaria conoides (J. Agardh). The aqueous extract of T. conoides was used to synthesize iron nanoparticles (NPs). The synthesized iron NPs were characterized by X –ray diffraction analysis, Scanning Electron Microscopy, and Transmission Electron Microscopy. The synthesized NPs showed potent activity against DLD1 and HeLa cell lines.

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Section: Anticancer Activity Of Iron Npsmentioning

confidence: 85%

Green synthesis of iron nanoparticles using aqueous extract of Turbinaria conoides (J. Agardh) and their anticancer properties

Bensy

Christobel

2021

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“…Similarly, Sathishkumar et al [ 31 ] have demonstrated that the biosynthesis of Au-NPs with Couroupita guianensis fruits showed potential free radical scavenging activity on DPPH, reducing power assay, hydroxyl radical scavenging, and superoxide radical scavenging assays. Lydia et al (2020) [ 32 ] reported that Au-NPs synthesized from Punica granatum revealed significant DPPH (23.6 ± 1.5 to 62.5 ± 1.8%) and hydrogen peroxide (21.6 ± 1.3 to 62.8 ± 1.8%) radical scavenging activity. Similarly, the calcinated form of the titanium oxide nanoparticles exhibited considerable free radical scavenging abilities using assays such as DPPH (IC 50 of 95.32 ± 0.43), NO (IC 50 of 110.03 ± 0.99 μg/mL), superoxide (IC 50 of 136.27 ± 0.63 μg/mL), and ABTS method (IC 50 of 119.11 ± 0.94 μg/mL) [ 17 , 25 ].…”

Section: Resultsmentioning

confidence: 99%

Process Optimization for the Bioinspired Synthesis of Gold Nanoparticles Using Cordyceps militaris, Its Characterization, and Assessment of Enhanced Therapeutic Efficacy

Gawas,

Ayyanar,

Gurav

et al. 2023

Pharmaceuticals

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The promising therapeutic implications of nanoparticles have spurred their development for biomedical applications. An eco-friendly methodology synthesizes gold nanoparticles using Cordyceps militaris, an edible mushroom (Cord-Au-NPs), using a quality-by-design approach (central composite design). UV-visible spectroscopy analysis revealed an absorption peak at 540–550 nm, thus confirming the synthesis of gold nanoparticles. Cord-Au-NPs have a crystalline structure, as evidenced by the diffraction peaks. The zeta potential value of −19.42 mV signifies the stability of Cord-Au-NPs. XRD study shows gold facets and EDX analysis revealed a strong peak of spherical nanoparticles in the gold region with a mean particle size of 7.18 nm and a polydispersity index of 0.096. The obtained peaks are closely associated with phenolic groups, lipids, and proteins, as examined by FTIR, suggesting that they function as the reducing agent. Cord-Au-NPs exhibited dose-dependent antioxidant, antidiabetic, and antibacterial activity. The method is eco-friendly, nontoxic, less time-consuming, and does not use synthetic materials, leading to higher capabilities in biomedical applications.

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“…Pomegranate seeds (PS) are rich in unsaturated–polyunsaturated fatty acids, vitamins, sugar, polysaccharides, polyphenols, and minerals. The PS extract and oil are characterized by a great amount of fatty acids, linoleic acid, gallic acid, and EA [ 60 ]. The pomegranate leaves (PL) are rich with hydrolysable tannins such as granatins A and B, while there is only a trace of punicalagins and punicalins.…”

Section: Pomegranate Fruit (Pf)mentioning

confidence: 99%

Pomegranate: A Source of Multifunctional Bioactive Compounds Potentially Beneficial in Alzheimer’s Disease

et al. 2023

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Pomegranate fruit (PF) is a fruit rich in nutraceuticals. Nonedible parts of the fruit, especially peels, contain high amounts of bioactive components that have been largely used in traditional medicine, such as the Chinese, Unani, and Ayurvedic ones, for treating several diseases. Polyphenols such as anthocyanins, tannins, flavonoids, phenolic acids, and lignans are the major bioactive molecules present in PF. Therefore, PF is considered a source of natural multifunctional agents that exert simultaneously antioxidant, anti-inflammatory, antitumor, antidiabetic, cardiovascular, and neuroprotective activities. Recently, several studies have reported that the nutraceuticals contained in PF (seed, peel, and juice) have a potential beneficial role in Alzheimer’s disease (AD). Research suggests that the neuroprotective effect of PF is mostly due to its potent antioxidant and anti-inflammatory activities which contribute to attenuate the neuroinflammation associated with AD. Despite the numerous works conducted on PF, to date the mechanism by which PF acts in combatting AD is not completely known. Here, we summarize all the recent findings (in vitro and in vivo studies) related to the positive effects that PF and its bioactive components can have in the neurodegeneration processes occurring during AD. Moreover, considering the high biotransformation characteristics of the nutraceuticals present in PF, we propose to consider the chemical structure of its active metabolites as a source of inspiration to design new molecules with the same beneficial effects but less prone to be affected by the metabolic degradation process.

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Photo-activated synthesis and characterization of gold nanoparticles from Punica granatum L. seed oil: An assessment on antioxidant and anticancer properties for functional yoghurt nutraceuticals

Cited by 37 publications

References 19 publications

Green synthesis of iron nanoparticles using aqueous extract of Turbinaria conoides (J. Agardh) and their anticancer properties

Green synthesis of iron nanoparticles using aqueous extract of Turbinaria conoides (J. Agardh) and their anticancer properties

Process Optimization for the Bioinspired Synthesis of Gold Nanoparticles Using Cordyceps militaris, Its Characterization, and Assessment of Enhanced Therapeutic Efficacy

Pomegranate: A Source of Multifunctional Bioactive Compounds Potentially Beneficial in Alzheimer’s Disease

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