Phosphorylierungsmittel — Bauprinzip und Reaktionsweise

Abstract

Koordinationspolyedern. Diese Forderung erfullen z. B. Elemente der B-Gruppen des Peroidensystems. Nach Orgel [81]

The synthesis of 3‐phosphonoalanine, phosphonopyruvic acid and phosphonolactic acid

“…Presumably departure of Nz from -H 0 3 P -CH2 -CH-(-N ' 2) -COOH is accompanied by scission of the P-C bond rather than attack of 01 on C2, the usual reaction when 2-amino acids are diazotized. The reaction is thus like the diazotization of aminoethylphosphonic acid studied by Mastalerz and Richtarski (1971), and closely analogous to the Conant-Swan breakdown in base of 2-haloalkylphosphonic acids (see Maynard and Swan, 1963); it is one of the reactions analysed by Clark et al (1964) as a P-XYZ system in which Z accommodates electrons and it is similar to the mechanism of natural splitting of the C-P bond (La Nauze et al, 1977;Olsen et al, 1988) and to the release of phosphate when 1-aminoalkylphosphonic acids react with ninhydrin (Warren, 1966). When, however, 2 mol/mol HBr was added, no phosphate was released (and bromo acid rather than hydroxy acid was the main product).…”

Nonenzymatie Formation of Energy Rich Phosphates in the Course of Imidazole Oxidation with Fenton's Reagent

“…Radical mechanisms in relation to these processes have been stressed rather exceptionally [9]. Usually twoelectron processes have been considered in phosphorylation reactions [10] and general interest is presently focused on vectorial processes [11] in heterogenic systems, rather than on homogeneous reactions. Conspicuously enough, one electron processes are involved in the successful model systems of Wieland and Bäuerlein [12].…”

Chemical Warfare Agents

“…(3) The leaving group X is typically a halogen or pseudohalogen, aryloxy -, thioxy -or phosphate -group [7] . The choice of the right leaving group is a delicate task.…”