Phosphorylation promotes the endonuclease-like activity of human centrin 2

Yang, Jing; Zhao, Yaqin; Yang, Binsheng

doi:10.1039/d2ra03402f

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The Ways To Control Xpa1

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2022

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“…Of note, another initially centrosomal protein is involved in the NER process: centrin 2 (human centrin 2, HsCen2, CEN2). In the nucleus, HsCen2 forms a stable XPC–RAD23B–CEN2 complex [ 164 ], influences the XPA–RPA binding to DNA [ 165 ], and even possesses an endonuclease-like activity [ 166 ].…”

Section: The Ways To Control Xpamentioning

confidence: 99%

The XPA Protein—Life under Precise Control

Krasikova

Lavrik

Rechkunova

2022

Cells

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Nucleotide excision repair (NER) is a central DNA repair pathway responsible for removing a wide variety of DNA-distorting lesions from the genome. The highly choreographed cascade of core NER reactions requires more than 30 polypeptides. The xeroderma pigmentosum group A (XPA) protein plays an essential role in the NER process. XPA interacts with almost all NER participants and organizes the correct NER repair complex. In the absence of XPA’s scaffolding function, no repair process occurs. In this review, we briefly summarize our current knowledge about the XPA protein structure and analyze the formation of contact with its protein partners during NER complex assembling. We focus on different ways of regulation of the XPA protein’s activity and expression and pay special attention to the network of post-translational modifications. We also discuss the data that is not in line with the currently accepted hypothesis about the functioning of the XPA protein.

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Section: The Ways To Control Xpamentioning

confidence: 99%