2000
DOI: 10.1016/s1095-6433(00)80005-7
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Phosphorylation of the metal-activated transcription factor in response to metals

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“…2000). The direct effect of metal ions in transcription, has been demonstrated in Eukaryotes (Adams and Freedman 2000). However, this effect seems to be mediated by the small (60 amino acid residues) cysteine‐rich proteins, metallothionein, that are ubiquitous among Eukaryotes (Hammer 1986).…”
Section: Discussionmentioning
confidence: 99%
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“…2000). The direct effect of metal ions in transcription, has been demonstrated in Eukaryotes (Adams and Freedman 2000). However, this effect seems to be mediated by the small (60 amino acid residues) cysteine‐rich proteins, metallothionein, that are ubiquitous among Eukaryotes (Hammer 1986).…”
Section: Discussionmentioning
confidence: 99%
“…However, this effect seems to be mediated by the small (60 amino acid residues) cysteine‐rich proteins, metallothionein, that are ubiquitous among Eukaryotes (Hammer 1986). Phosphorylation of the metal‐activated transcription factor in response to metals, has been demonstrated (Adams and Freedman 2000), and several potential metallothionein‐binding transcription factors (MTF‐1), have been identified in animals (Searle 1990). Similarly, a protein in mice, that is responsible for Zinc‐inducible MT‐I transcription, has been isolated (Radtke et al.…”
Section: Discussionmentioning
confidence: 99%