Phosphorylation of the metal-activated transcription factor in response to metals

Adams, Timothy K; Freedman, Jonathan H.

doi:10.1016/s1095-6433(00)80005-7

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“…2000). The direct effect of metal ions in transcription, has been demonstrated in Eukaryotes (Adams and Freedman 2000). However, this effect seems to be mediated by the small (60 amino acid residues) cysteine‐rich proteins, metallothionein, that are ubiquitous among Eukaryotes (Hammer 1986).…”

Section: Discussionmentioning

confidence: 99%

“…However, this effect seems to be mediated by the small (60 amino acid residues) cysteine‐rich proteins, metallothionein, that are ubiquitous among Eukaryotes (Hammer 1986). Phosphorylation of the metal‐activated transcription factor in response to metals, has been demonstrated (Adams and Freedman 2000), and several potential metallothionein‐binding transcription factors (MTF‐1), have been identified in animals (Searle 1990). Similarly, a protein in mice, that is responsible for Zinc‐inducible MT‐I transcription, has been isolated (Radtke et al.…”

Section: Discussionmentioning

confidence: 99%

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Metal ion enhancement of fungal growth, gene expression and aflatoxin synthesis in Aspergillus flavus: RT-PCR characterization

Cuero

Ouellet

et al. 2003

Journal of Applied Microbiology

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Aims:To determine the effect of mineral ions (e.g., Zn 2+ , Cu 2+ , and Fe 2+ ) on the enhancement of fungal growth, total RNA, aflatoxin pathway gene expression, and production of aflatoxin and its precursor O-methylsterigmatocystin (OMST). Methods and Results:The influence of the metal ions, as a single or mixed treatments, was observed in submerged cultures of toxigenic Aspergillus flavus through changes in the fungal RNA or aflatoxin pathway gene (omtA) by reverse transcription-polymerase chain reaction (RT-PCR) levels, and also in fungal dry-weight accumulation, aflatoxin and OMST production. Conclusions: The ion treatments induced changes of fungal total RNA, mRNA levels, associate fungal growth, biosynthesis of aflatoxin and OMST, and enhanced expression of RT-PCR. Significance and Impact of Study: Demonstrates at the cellular and molecular level, the significant effects of metal ions on both fungal growth and production of aflatoxin.

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Section: Discussionmentioning

confidence: 99%