Abstract:Maurocalcine (MCa) is a 33-amino acid peptide isolated from the venom of Scorpio maurus palmatus, a Tunisian scorpion. It possesses efficient cell penetration properties and has been shown to strongly modify ryanodine receptor (RyR1) channel behavior by increasing open probability and inducing a long-lasting subconductance state. The amino acid residue threonine at position 26 belongs to a putative phosphorylation site within MCa sequence. We investigated the effect of a) T26 phosphorylation (MCa T26Phospho) b… Show more
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