2015
DOI: 10.4103/1008-682x.156119
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Phosphorylation of Izumo1 and Its Role in Male Infertility

Abstract: Izumo1 is a testis-specific gene product, whose function is essential for sperm-egg fusion. Throughout its lifespan, Izumo1 is posttranslationally modified, being both N-linked glycosylated on its extracellular domain and phosphorylated on the intracellular C-terminal tail. Within the caput regions of the rat epididymis, two phosphorylation events have been documented. However, as sperm pass through the epididymis, this cytoplasmic portion of Izumo1 has been shown to contain up to seven phosphorylation sites. … Show more

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Cited by 11 publications
(4 citation statements)
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“…Moreover, a similar relocation has been reported in mouse sperm during acrosome reaction. Mice IZUMO1 relocates from both the inner and outer acrosome membranes to the equatorial segment due to the acrosome reaction [30]. It is worth noting that IZUMO1-staining was unexpectedly found in the sperm tail of pre-frozen, but not frozen-thawed, boar sperm.…”
Section: Discussionmentioning
confidence: 99%
“…Moreover, a similar relocation has been reported in mouse sperm during acrosome reaction. Mice IZUMO1 relocates from both the inner and outer acrosome membranes to the equatorial segment due to the acrosome reaction [30]. It is worth noting that IZUMO1-staining was unexpectedly found in the sperm tail of pre-frozen, but not frozen-thawed, boar sperm.…”
Section: Discussionmentioning
confidence: 99%
“…Although the mechanisms and molecules in sperm-oocyte fusion on the sperm side are closely related to male infertility, little is still known about the mechanisms or the molecules involved [ 12 ]. In recent years, efforts have been made toward the identification of the molecular players and their function, and several molecules on the egg or the sperm side have been found to be essential or nearly essential [ 13 ]. Herein, this review mainly focuses on the factors implicated strongly in the sperm-egg fusion process on the sperm side to explain the potential mechanisms of male infertility.…”
Section: Sperm-oocyte Fusion Is a Critical Step In Fertilizationmentioning
confidence: 99%
“…In the caput regions of rat epididymis, there are only two phosphorylation sites in the cytoplasmic tail of IZUMO1. Nevertheless, when the sperm pass through the epididymis, the intracellular C-terminal tail of IZUMO1 is phosphorylated at seven sites [ 13 ]. In some infertile males, IZUMO1 is present in their sperm as its nonphosphorylated form or the number of phosphorylation sites is reduced compared with those in fertile men.…”
Section: Izumo1 Is Essential For Sperm-oocyte Fusionmentioning
confidence: 99%
“…The Izumo sperm egg fusion gene ( IZUMO1 ) is a crucial member of the immunoglobulin superfamily and plays a crucial role in spermatogenesis, sperm egg interaction, and fusion [6,7,8,9]. As reported by Kim [7] the expression of IZUMO1 mRNA was mainly in the testis and sperm and performed an important part in fertilization.…”
Section: Introductionmentioning
confidence: 99%