Phosphorylation of disordered proteins tunes local and global intramolecular interactions
Emery T. Usher,
Martin J. Fossat,
Alex S. Holehouse
Abstract:Protein post-translational modifications, such as phosphorylation, are important regulatory signals for diverse cellular functions. In particular, intrinsically disordered protein regions (IDRs) are subject to phosphorylation as a means to modulate their interactions and functions. Toward understanding the relationship between phosphorylation in IDRs and specific functional outcomes, we must consider how phosphorylation affects the IDR conformational ensemble. Various experimental techniques are suited to inte… Show more
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