Abstract:Tau proteins are commonly found in neural cells and provide a variety of functions, the most notable being the regulation of microtubule stability and spacing. Tau aggregation has been implicated in several neurodegenerative diseases, namely dementia and Alzheimer's, making tau‐based therapeutics an area of high research interest. Site‐specific phosphorylation of tau has been observed to direct its behavior but can also result in a lower binding affinity of tau to microtubules, increased propensity of tau to a… Show more
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.