Phosphorylation and association with the transcription factor Atf1 regulate localization of Spc1/Sty1 stress-activated kinase in fission yeast

Gaits, Frédérique; Degols, Geneviève; Shiozaki, Kazuhiro; Russell, Paul

doi:10.1101/gad.12.10.1464

Cited by 145 publications

(175 citation statements)

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“…In its inactive state, the kinase is cytoplasmic, but moves to the nucleus upon activation (Gaits et al 1998). The exact mechanism of this regulated localization is not yet clear, but nuclear accumulation is coincident with loss of Sty1…”

Section: The Signal Transduction Pathwaysmentioning

confidence: 99%

Stress‐activated signalling pathways in yeast

1998

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Eukaryotic cells have developed response mechanisms to combat the harmful effects of a variety of stress conditions. In the majority of cases, such responses involve changes in the gene expression pattern of the cell, leading to increased levels and activities of proteins that have stress-protective functions. Over the last few years, considerable progress has been made in understanding how stress-dependent transcriptional changes are brought about, and it transpires that the underlying mechanisms are highly conserved, being similar in organisms ranging from yeast to man. Many of the stress signals derive from the extracellular environment and accordingly these signals require transduction from the cell surface to the nucleus. This is accomplished through stress-activated signalling pathways, key amongst which are the highly conserved stress-activated MAP kinase pathways. Stimulation of these pathways leads to the increased activity of specific transcription factors and consequently the increased expression of certain stress-related genes. In this review, we focus on the progress that has been made in understanding these stress responses in yeast.

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Section: The Signal Transduction Pathwaysmentioning

confidence: 99%

Stress‐activated signalling pathways in yeast

1998

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“…Moreover, atf1 mutants show defects in stress-and Sty1p-dependent transcription. However, these mutants only display a subset of the stress sensitivities seen in sty1 mutants, suggesting that Sty1p controls other as yet unidentified proteins Wilkinson et al, 1996;Gaits et al, 1998).…”

Section: Introductionmentioning

confidence: 99%

Global Transcriptional Responses of Fission Yeast to Environmental Stress

Chen

Toone

Mata

et al. 2003

MBoC

733

988

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We explored transcriptional responses of the fission yeast Schizosaccharomyces pombe to various environmental stresses. DNA microarrays were used to characterize changes in expression profiles of all known and predicted genes in response to five stress conditions: oxidative stress caused by hydrogen peroxide, heavy metal stress caused by cadmium, heat shock caused by temperature increase to 39°C, osmotic stress caused by sorbitol, and DNA damage caused by the alkylating agent methylmethane sulfonate. We define a core environmental stress response (CESR) common to all, or most, stresses. There was a substantial overlap between CESR genes of fission yeast and the genes of budding yeast that are stereotypically regulated during stress. CESR genes were controlled primarily by the stress-activated mitogen-activated protein kinase Sty1p and the transcription factor Atf1p. S. pombe also activated gene expression programs more specialized for a given stress or a subset of stresses. In general, these "stress-specific" responses were less dependent on the Sty1p mitogen-activated protein kinase pathway and may involve specific regulatory factors. Promoter motifs associated with some of the groups of coregulated genes were identified. We compare and contrast global regulation of stress genes in fission and budding yeasts and discuss evolutionary implications.

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“…In particular, how is transcriptional specificity attained by the activated MAPK such that the correct pattern of gene expression occurs in response to a specific stimulus? Two papers in this issue (Gaits et al 1998;Toone et al 1998) suggest that regulated and interdependent nucleocytoplasmic transport of both the MAPK and transcription factor play an important role in the answer to these questions.…”

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confidence: 99%