“…Its use has been for a long time limited to environmental applications focused on the efficient aqueous removal and recovery of different water contaminants, such as Ni 2+ , Pb 2+ , Cu 2+ , malachite green, and methyl violet, among others. − It has been extensively used also in food, cosmetics, and pharmaceutical industries. , In the pharmaceutical area, xanthan-based hydrogels have been mainly used as drug delivery formulations for dermatological use, although there are also recent examples of XG being a key component of ocular and orally administered hydrogel formulations. , In most of them, XG is generally combined with other synthetic and natural polymers, such as galactomannan, lignin, chitosan and cellulose derivatives, , konjac gum, and polyacrylic acid, among others. A wide variety of both hydrophilic and hydrophobic drugs have been incorporated in XG-based hydrogel matrices, such as curcumin, fluticasone propionate, cyclosporine, carbamazepine, fenoverine, caffeine, indomethacin, ibuprofen, diclofenac sodium, buspirone, theophylline, etc., targeting applications − ,− that range from topical delivery, skin wound healing, and local treatment of oral ulcerative lesions and ophthalmic diseases to gastroretention, epilepsy, and neuropathic pain following oral administration, as well as healing of surgical interventions.…”