Phosphorylated STAT3 expression in hematopoietic stem cell transplant-associated large granular lymphocytic leukemia

Liang, Cynthia S.; Quesada, Andres; Goswami, Maitrayee; Johnston, P. K.; Brown, Robert E.; Jaso, Jesse Manuel

doi:10.1038/bmt.2015.336

Cited by 6 publications

(5 citation statements)

References 9 publications

(19 reference statements)

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“…Though no STAT3/STAT5b mutations have been found in alloHSCT recipients with LGL expansions to date, Liang et al found that a significant subset of such patients showed nuclear expression of phosphorylated STAT3 protein by immunohistochemistry, which has been associated with constitutive activation of the STAT3 pathway in de novo LGLL, even in the absence of somatic mutations [ 60 , 190 ]. This finding supports the notion that such cases may share a pathogenesis similar to those of non-transplantation related cases.…”

Section: Post-allogeneic Hematopoietic Stem Cell Transplantationmentioning

confidence: 99%

Persistent Large Granular Lymphocyte Clonal Expansions: “The Root of Many Evils”—And of Some Goodness

Bravo-Pérez

Carrillo-Tornel

García-Torralba

et al. 2022

Cancers

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Large granular lymphocyte leukemia (LGLL) is a chronic disease of either mature phenotype cytotoxic CD3+ T lymphocytes or CD3- NK cells. LGLL diagnosis is hampered by the fact that reactive persistent clonal LGL expansions may fulfill the current criteria for LGLL diagnoses. In addition to the presence of characteristic clinical and hematological signs such as anemia or neutropenia, LGLL/LGL clonal expansions have been associated with an array of conditions/disorders. We review here the presence of these persistent clonal expansions in autoimmune, hematological disorders and solid neoplasms and after hematopoietic stem cell transplantation. These associations are a unique translational research framework to discern whether these persistently expanded LGL clones are causes or consequences of the concomitant clinical settings and, more importantly, when they should be targeted.

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Section: Post-allogeneic Hematopoietic Stem Cell Transplantationmentioning

confidence: 99%

Persistent Large Granular Lymphocyte Clonal Expansions: “The Root of Many Evils”—And of Some Goodness

Bravo-Pérez

Carrillo-Tornel

García-Torralba

et al. 2022

Cancers

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“…In a report, IHC was used to assess the nuclear localization of pSTAT3 in seven patients who developed LGLL following SCT [ 37 ]. More recently, Liang CS et al showed that pSTAT3 was expressed in SCT-associated T-LGLL by IHC [ 38 ]. As a result, specific STAT3 inhibitors have been evaluated as novel therapeutic agents for the treatment of T-LGLL [ 39 ].…”

Section: Introductionmentioning

confidence: 99%

“…At the end of the follow-up, 4 patients were alive, including one with persistent disease and three with progressive disease. Three patients died due to complications of disease, including one with persistent disease and two with progressive disease [ 38 ].…”

Section: Introductionmentioning

confidence: 99%

Large granular lymphocytosis after transplantation

et al. 2017

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Post-transplant lymphoproliferative disorders (PTLD) represent a heterogeneous group of diseases that occur following transplantation. Large granular lymphocytic (LGL) lymphocytosis is one type of PTLD, ranging from reactive polyclonal selflimited expansion to oligo/monoclonal lymphocytosis or even to overt leukaemia.LGL lymphocytosis in transplant recipients may present as a relatively indolent version of the condition and may be more common than reported, but its natural history and clinical course have not been well described, and the lack of a reliable classification system has limited studies on this disease. Patients with unexplained cytopenias, autoimmune manifestations, or unexpected remissions may be mislabelled. The purpose of this review was to evaluate the clinical features, immunophenotypes, etiopathogenesis, diagnosis, outcomes and treatment of post-transplantation LGL lymphocytosis. In conclusion, LGL lymphocytosis is a frequent occurrence after transplantation that correlates with certain procedural variables and post-transplant events. LGL lymphocytosis should be considered in patients with unexplained lymphocytosis or when pancytopenia develops after transplantation. The diagnosis of LGL lymphocytosis requires a demonstration of monoclonality, but clonality does not indicate malignancy. Additional studies are necessary to further delineate the potential effects of large granular lymphocytes in the long-term prognosis of posttransplant patients.

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“…While our patient had a 30-year history of osteoarthritis, he had negative titers for rheumatoid factor, anti-cyclic citrullinated peptide, and antinuclear antibodies. Definitively establishing the clonality of the NK cells is formidable, although the monotypic expression of killer Ig-like receptor isoforms (KIR; CD158a/b/c) may be helpful [ 10 - 12 ]. The presence of recurrent STAT3 and STAT5B mutations in 30% to 40% of both T- and NK-cell LGL implies shared pathobiology but in and of themselves are not diagnostic [ 13 - 14 ].…”

Section: Discussionmentioning

confidence: 99%

Florid Pulmonary Mycobacterium avium-intracellulare Infection in a Patient With Large Granular Lymphocytic (LGL) Leukemia on Chronic Cyclophosphamide

Kojadinovic

Mundi

2021

Cureus

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Phosphorylated STAT3 expression in hematopoietic stem cell transplant-associated large granular lymphocytic leukemia

Cited by 6 publications

References 9 publications

Persistent Large Granular Lymphocyte Clonal Expansions: “The Root of Many Evils”—And of Some Goodness

Persistent Large Granular Lymphocyte Clonal Expansions: “The Root of Many Evils”—And of Some Goodness

Large granular lymphocytosis after transplantation

Florid Pulmonary Mycobacterium avium-intracellulare Infection in a Patient With Large Granular Lymphocytic (LGL) Leukemia on Chronic Cyclophosphamide

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