Abstract:KRAS/ERK pathway phosphorylates DICER1, causing its nuclear translocation, and phosphomimetic
Dicer1
contributes to tumorigenesis in mice. Mechanisms through which phospho-DICER1 regulates tumor progression remain undefined. While DICER1 canonically regulates microRNAs (miRNA) and epithelial-to-mesenchymal transition (EMT), we found that phosphorylated nuclear DICER1 (phospho–nuclear DICER1) promotes late-stage tumor progression in mice with oncogenic
Kras
, inde… Show more
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