Phosphorus dendrimers and dendrons functionalized with the cage ligand tris(1,2‐dimethylhydrazino)diphosphane

Versatile Reactivity of Cyclic 1,2-Dimethylhydrazinodiphosphines

“…The reaction was monitored by 31 P NMR, which displayed first, besides the singlet of the starting compound 1 ( δ = 108 ppm) the presence of two doublets at δ = +95 (P III ) and –4 (P=N) ppm ( 3 J PP = 79 Hz), corresponding to the reaction on a single phosphorus atom (compound 2 in Scheme ). These values compare well with those obtained for the single reaction with the azide N 3 (CH 2 ) 3 NH 2 ( δ = 95 and 3 ppm, 3 J PP = 75 Hz) . Continuing the reaction induces the appearance of another singlet at δ = –7 ppm, which corresponds to the reaction on both sides of compound 1 , to afford compound 3 .…”

“…Previous work reported a straightforward reaction with a few azides, in particular with PhN 3 , Ph 2 P(O)N 3 ,, , and (PhO) 2 P(O)N 3 , . We have also reported that in the case of the azide N 3 (CH 2 ) 3 NH 2 , reaction on only one or on both phosphorus atoms occurred . Unexpectedly, the reaction of the cage compound 1 with Me 3 SiN 3 never went to completion, even after 5 weeks at 70 °C, with addition of two additional equiv.…”

Direct Binding of a Redox Protein for Single‐Molecule Electron Transfer Measurements

“…Different synthetic strategies were developed in order to incorporate THDP and the corresponding mononuclear Ru complex either on the surface of phosphorus dendrimers or at the focal point of phosphorus dendrons in the hope to observe a positive dendritic effect, i.e., an enhancement of the catalytic activity when moving from the monomer to dendrimer decorated with several monomer units 53. Two of these complexes54 are shown in Figure 5 but their catalytic properties are not yet illustrated.…”

First-in-Class Phosphorus Dendritic Framework, a Wide Surface Functional Group Palette Bringing Noteworthy Anti-Cancer and Anti-Tuberculosis Activities: What Lessons to Learn?

“…Nevertheless, several strategies have been implemented to solve this issue in order to prepare high-generation dendrimers. For instance, click chemistry has been used to prepare sophisticated dendrimers [ 5 ]; accelerated synthesis of phosphorus-containing dendrimers from orthogonal systems has been developed using two-branched AB 5 and CD 5 monomers for condensation and Staudinger reactions [ 6 ]; broadening of the phosphorus dendrimer design can be highlighted by the preparation of hybrid phosphorus–viologen dendrimers, as well as macromolecular asterisks with several types of cores, including 1,6-diphosphine [ 7 ], phosphonate-phosphine [ 8 ] and cage diphosphine [ 9 ]; and onion peel dendritic structures [ 10 ] and Janus dendrimers [ 11 ] have also been developed.…”