Phosphorus ans an early predictive factor in patients with acute liver failure1

Baquerizo, Angeles; Anselmo, Dean M.; Shackleton, Christopher R.; Chen, Teng-Wei; Cao, Carlos; Weaver, Michael; Gornbein, Jeffrey; Geevarghese, Sunil K.; Nissen, Nicholas N.; Farmer, Douglas G.; Demetriou, Achilles A.; Busuttil, Ronald W.

doi:10.1097/01.tp.0000063219.21313.32

Cited by 95 publications

(62 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Furthermore, a contemporary analysis of 719 major liver resections also reported increased postoperative morbidity and mortality associated with the lack of HP rather than its presence (27). Our findings suggest that, rather than bearing an (28). Finally, the only other large contemporary analysis of post-hepatectomy HP indicated that patients presenting an elevated phosphate on postoperative day 2 were at higher risk of liver insufficiency (27).…”

Section: Discussionmentioning

confidence: 68%

Hypophosphatemia and recovery of post-hepatectomy liver insufficiency

Hallet

Karanicolas

Zih

et al. 2016

Hepatobiliary Surg. Nutr.

View full text Add to dashboard Cite

Recent major advancements in the technique and intraoperative management have significantly improved outcomes of hepatic surgery (1). However, post-operative liver failure remains a significant complication, responsible for 60% to 100% of deaths after liver resection (1-4).Considering the rising prevalence of parenchymal liver disease and the increased use of potentially hepatotoxic neoadjuvant chemotherapy, more patients are and will be at risk of post-hepatectomy liver failure (PHLF) (5,6).While initial liver insufficiency (ILI), whereby serum bilirubin and international normalized ratio (INR) rise in the first 24 to 72 hours following hepatectomy, is frequent, it is most often transient (7) 65.0%; P=0.03). Conclusions:In patients who experience post-hepatectomy ILI, HP is associated with improved recovery, potentially indicating more efficient liver regeneration. Further studies should explore the usefulness of posthepatectomy HP as an early prognostic factor of recovery from ILI.

show abstract

Section: Discussionmentioning

confidence: 68%

Hypophosphatemia and recovery of post-hepatectomy liver insufficiency

Hallet

Karanicolas

Zih

et al. 2016

Hepatobiliary Surg. Nutr.

View full text Add to dashboard Cite

show abstract

“…169,171 The significance of hypophosphataemia after hepatic surgery has been debated. Some studies suggest that low phosphate indicates better prognosis, 172 while others suggest that it may delay postoperative recovery. 70 However, replacement of phosphate has been shown to improve recovery of hepatic function.…”

Section: Increased Lossmentioning

confidence: 99%

Phosphate homeostasis and disorders

2014

View full text Add to dashboard Cite

Recent studies of inherited disorders of phosphate metabolism have shed new light on the understanding of phosphate metabolism. Phosphate has important functions in the body and several mechanisms have evolved to regulate phosphate balance including vitamin D, parathyroid hormone and phosphatonins such as fibroblast growth factor-23 (FGF23). Disorders of phosphate homeostasis leading to hypo-and hyperphosphataemia are common and have clinical and biochemical consequences. Notably, recent studies have linked hyperphosphataemia with an increased risk of cardiovascular disease. This review outlines the recent advances in the understanding of phosphate homeostasis and describes the causes, investigation and management of hypo-and hyperphosphataemia.

show abstract

“…In fact, it is illusory to think that a single set of criteria is relevant to FH of any cause. For this reason, a specific score according to the aetiology has been proposed: non-paracetamol-induced ALF in KCH criteria, blood arterial lactate [47], serum phosphate [48] [49], α-fetoprotein [50] in paracetamol-induced ALF, prognostic factors for HAV infection-related FH [51], a prognostic scoring model for liver transplantation in patients with non-paracetamol-related ALF [52], prognostic factors of Amanita phalloides poisoning [53] [54].…”

Section: Liver Transplantmentioning

confidence: 99%

Fulminant Hepatitis: Definitions, Causes and Management

Morabito¹,

Adebayo²

2014

Health

View full text Add to dashboard Cite

Fulminant hepatitis (FH) is a rare and devastating syndrome caused by a variety of hepatic insults. It characterized by severe metabolic derangements, neurologic complications and ultimately, multiorgan failure. Liver transplantation is the gold standard therapy for patients with irreversible FH. The major areas of current research in this field include the development of: hepatic support devices, strategies to accelerate hepatic regeneration and criteria for accurate prognostic classification of patients. This review aims to focus on the definitions, aetiologies and management strategies for FH.

show abstract

Phosphorus ans an early predictive factor in patients with acute liver failure1

Abstract: Hypophosphatemia and early phosphorus administration are associated with a good prognosis in ALF, whereas hyperphosphatemia is predictive of poor recovery.

Cited by 95 publications

References 26 publications

Hypophosphatemia and recovery of post-hepatectomy liver insufficiency

Hypophosphatemia and recovery of post-hepatectomy liver insufficiency

Phosphate homeostasis and disorders

Fulminant Hepatitis: Definitions, Causes and Management

Contact Info

Product

Resources

About