Phosphorescence and ODMR study of the binding interactions of acetylcholine receptor α‐subunit peptides with α‐cobratoxin

Tringali, Arthur E; Pearce, Suman Frieda A.; Hawrot, Edward; Brenner, Howard

doi:10.1016/0014-5793(92)81279-u

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Postsynaptic Neurotoxins Postsynaptic Neurotoxins1

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1993

1995

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“…This could explain the higher affinity of the neurotoxins compared to acetylcholine. It is also consistent with a study by Trp phosphorescence and optical detection of magnetic resonance (ODMR), which indicated an increased hydrophobic Trp environment in synthetic peptides reproducing the binding-site regions of the AChR, upon binding on a-cobratoxin (45).…”

Section: Postsynaptic Neurotoxins Postsynaptic Neurotoxinssupporting

confidence: 90%