Phosphonium surfactant stabilised silver nanoparticles. Correlation of surfactant structure with physical properties and biological activity of silver nanoparticles

Pisárčik, Martin; Lukáč, Miloš; Jampílek, Josef; Bilka, František; Bilková, Andrea; Pašková, Ľudmila; Devı́nsky, Ferdinand; Horáková, Renáta; Opravil, Tomáš

doi:10.1016/j.molliq.2020.113683

Cited by 15 publications

(15 citation statements)

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“…As the published studies indicate, AgNPs are stabilized by the formation of a protective surfactant bilayer composed of single-chain or gemini surfactant molecules. The formation and composition of surfactant-capped AgNPs and their organic shell are mostly documented by the changes in the UV-VIS spectra due to the plasmon resonance effect and changes in nanoparticle surface charge represented by the variation of zeta potential [ 49 , 51 , 52 , 53 , 54 ].…”

Section: Methodsmentioning

confidence: 99%

“…Cytotoxic activity of nanoparticles was tested by viability of HepG2 cells (ATCC HB-8065). Cell cultivation conditions are described in detail in [ 52 ]. Briefly, cells were seeded at 70% confluency into wells of 24-well culture plates and were incubated for 24 h. Then, the tested substances in increasing concentrations (0–60 μmol/L) were added and cells were incubated for the next 24 h. After the removing of medium and fixation with 50% ethanol, the percentage of the live cells was indicated by Janus Green B staining [ 57 ] with modifications described in [ 52 ].…”

Section: Methodsmentioning

confidence: 99%

“…Of the broad family of cationic surfactants, a special group of double-chain gemini surfactants with various molecular composition of surfactant spacer turned out to be potent stabilizers of AgNPs [ 49 , 50 ]. Our previous structure-property relationship studies of stabilization potential of bisammonium gemini surfactants [ 49 ], single-chain ammonium [ 51 ], and phosphonium [ 52 ] surfactants revealed the complex effect of various structural features in surfactant molecule on physical properties and biological activity of surfactant-stabilized AgNPs. The investigations within the present work are extended towards the group of phosphorus-containing surface-active molecules featuring a five-membered heterocyclic ring in the molecule hydrophilic part whose synthesis and aggregation properties we reported previously [ 29 ].…”

Section: Introductionmentioning

confidence: 99%

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Silver Nanoparticles Stabilized with Phosphorus-Containing Heterocyclic Surfactants: Synthesis, Physico-Chemical Properties, and Biological Activity Determination

et al. 2021

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Phosphorus-containing heterocyclic cationic surfactants alkyldimethylphenylphospholium bromides with the alkyl chain length 14 to 18 carbon atoms were used for the stabilization of silver nanodispersions. Zeta potential of silver nanodispersions ranges from +35 to +70 mV, which indicates the formation of stable silver nanoparticles (AgNPs). Long-chain heptadecyl and octadecyl homologs of the surfactants series provided the most intensive stabilizing effect to AgNPs, resulting in high positive zeta potential values and smaller diameter of AgNPs in the range 50–60 nm. A comparison with non-heterocyclic alkyltrimethylphosphonium surfactants of the same alkyl chain length showed better stability and more positive zeta potential values for silver nanodispersions stabilized with heterocyclic phospholium surfactants. Investigations of biological activity of phospholium-capped AgNPs are represented by the studies of antimicrobial activity and cytotoxicity. While cytotoxicity results revealed an increased level of HepG2 cell growth inhibition as compared with the cytotoxicity level of silver-free surfactant solutions, no enhanced antimicrobial action of phospholium-capped AgNPs against microbial pathogens was observed. The comparison of cytotoxicity of AgNPs stabilized with various non-heterocyclic ammonium and phosphonium surfactants shows that AgNPs capped with heterocyclic alkyldimethylphenylphospholium and non-heterocyclic triphenyl-substituted phosphonium surfactants have the highest cytotoxicity among silver nanodispersions stabilized by the series of ammonium and phosphonium surfactants.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Silver Nanoparticles Stabilized with Phosphorus-Containing Heterocyclic Surfactants: Synthesis, Physico-Chemical Properties, and Biological Activity Determination

et al. 2021

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“…Therefore, it is very important to look for antifungal agents whose mechanism of action focuses on the specific structure of the fungal cell. The procedure for identifying agents with a new mode of action is relatively long and risky, and therefore the preparation of nanoparticles/nanoformulations of existing antifungal agents may be a first choice approach [1,[3][4][5][6][7][8].…”

Section: Extended Abstractmentioning

confidence: 99%

Impact of Nanoparticles on Pathogenic Fungi

Jampílek¹,

Pisárčik²

2020

Proceedings of the 5th World Congress on Recent Advances in Nanotechnology

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“…An increase of the efficacy of individual agents can be ensured by fixed-dose drug combinations or antimicrobially active matrices. In addition, many formulations also protect drugs from degradation [15][16][17][18][19].This contribution deals with the biological activity of various types of nanoparticles/nanomaterials against bacteria and mycobacteria species.…”

mentioning

confidence: 99%

Impact of Nanoparticles on Bacteria and Mycobacteria

Jampílek¹,

Pisárčik²

2021

Proceedings of the 6th World Congress on Recent Advances in Nanotechnology

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Bacterial infections represent an increasing worldwide threat. The number of untreatable diseases decreased after the 1950s due to the introduction of antimicrobial agents. However, since the 1980s, morbidity has risen again, and mortality due to respiratory infections, AIDS, COVID-19 and tuberculosis now represents about 85% of world mortality from infections. The increase in the number of new infections is caused by general immunosuppression (primarily by tumour treatment, administration of immunosuppressive agents, wide-spectrum antibiotics and corticoids), a significant increase in the number of diabetic, HIV or SARS-CoV-2 positive patients and development of resistance to commonly used drugs. The resistance of common pathogens to first-line drugs increased by up to 100% during the last decade. Moreover, the resistance of some strains to second-or third-line drugs can be found. Development of cross-resistant or multidrugresistant strains is also a great problem [1][2][3][4].Selection of resistant microorganisms is especially caused by irrational and unavailing application of antimicrobial agents in human, veterinary medicine and in agriculture. Among the most frequent resistant bacterial strains there are methicillin-resistant Staphylococcus aureus, vancomycin-resistant S. aureus, vancomycin-resistant enterococci, penicillinand macrolides-resistant Streptococcus pneumoniae, cotrimoxazol-resistant Escherichia coli, the 3rd generation of cephalosporin-resistant E. coli and Klebsiella pneumoniae and carbapenem-resistant E. coli, K. pneumoniae and Pseudomonas aeruginosa [3]. In addition, tuberculosis (TB) caused by Mycobacterium tuberculosis remains one of the world's deadliest communicable diseases. Multidrug-, extensively drug-and totally drug-resistant TB strains are a serious worldwide problem [5].Thus, it can be stated that significant resistance to antimicrobials can be found at both Gram-positive and Gramnegative bacteria that cause serious infections. Bacterial resistance may complicate the treatment of infections regardless of how mild these infections were at the early stage. The consequence can be a prolonged disorder, treatment failure and patient's death [6][7][8][9].It is increasingly complicated to design new classes of antimicrobial compounds suitable for following rational development, therefore R&D of new antimicrobials imply risks, and thus many pharmaceutical originator companies have continued in development of me-too drugs but which does not solve the basic problem of resistance. Thus increasing bacterial resistance refers to the urgency to design new effective antibacterial drugs [10].Application of nanotechnology represents an excellent alternative for improvement of existing antimicrobial drugs. Nanomaterials are an alternative approach to treating and mitigating infections caused by resistant bacteria. Microbial cells are unlikely to develop resistance to nanomaterials, because, in contrast to conventional antibiotics, they exert toxicity through various mechanisms [11][12][13][14]. Usin...

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Phosphonium surfactant stabilised silver nanoparticles. Correlation of surfactant structure with physical properties and biological activity of silver nanoparticles

Cited by 15 publications

References 62 publications

Silver Nanoparticles Stabilized with Phosphorus-Containing Heterocyclic Surfactants: Synthesis, Physico-Chemical Properties, and Biological Activity Determination

Silver Nanoparticles Stabilized with Phosphorus-Containing Heterocyclic Surfactants: Synthesis, Physico-Chemical Properties, and Biological Activity Determination

Impact of Nanoparticles on Pathogenic Fungi

Impact of Nanoparticles on Bacteria and Mycobacteria

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