Phosphonamidate Compounds for Butyrylcholinesterase Selective Inhibitors

Oh, Jintaek; Park, Jung‐Youl; Park, Kyoung Chan; Hwang, Ji Hyun; Park, Jeong Ho

doi:10.1002/bkcs.12126

Cited by 3 publications

(1 citation statement)

References 36 publications

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“…The synthesis and/or use of 3 has been reported in the context of electrode additives [37] and bioactive compound synthesis [38]; however, a slightly modified approach to 3 was used here to convert DOPO 1 to 3 via 4 (Scheme 1). A small-molecule X-ray crystallographic analysis of 3 was carried out (Figure 2).…”

Section: Phosphorus-containing Heterocycle Synthesismentioning

confidence: 99%

The Covalent Linking of Organophosphorus Heterocycles to Date Palm Wood-Derived Lignin: Hunting for New Materials with Flame-Retardant Potential

Davidson,

McKay,

Cordes

et al. 2023

Molecules

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Environmentally acceptable and renewably sourced flame retardants are in demand. Recent studies have shown that the incorporation of the biopolymer lignin into a polymer can improve its ability to form a char layer upon heating to a high temperature. Char layer formation is a central component of flame-retardant activity. The covalent modification of lignin is an established technique that is being applied to the development of potential flame retardants. In this study, four novel modified lignins were prepared, and their char-forming abilities were assessed using thermogravimetric analysis. The lignin was obtained from date palm wood using a butanosolv pretreatment. The removal of the majority of the ester groups from this heavily acylated lignin was achieved via alkaline hydrolysis. The subsequent modification of the lignin involved the incorporation of an azide functional group and copper-catalysed azide–alkyne cycloaddition reactions. These reactions enabled novel organophosphorus heterocycles to be linked to the lignin. Our preliminary results suggest that the modified lignins had improved char-forming activity compared to the controls. 31P and HSQC NMR and small-molecule X-ray crystallography were used to analyse the prepared compounds and lignins.

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Section: Phosphorus-containing Heterocycle Synthesismentioning

confidence: 99%

The Covalent Linking of Organophosphorus Heterocycles to Date Palm Wood-Derived Lignin: Hunting for New Materials with Flame-Retardant Potential

Davidson,

McKay,

Cordes

et al. 2023

Molecules

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Metal‐Free Doubly Decarboxylative Three‐Component Reaction: Synthesis of Propargyl Amines

Lim

Lee

2021

Asian J Org Chem

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Arylalkynoic acids, glyoxylic acid, and amines were reacted in the absence of transition metal catalysts to produce the corresponding arylpropargyl amines via double decarboxylation. In addition to cyclic secondary amines, non‐cyclic secondary amines also reacted with various substituted arylalkynoic acids and glyoxylic acid to afford the desired products in good yields. It was revealed that the carboxylic acid functionality was important for increasing the product yield.

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Synthesis of 4-substituted benzyl-2-triazole-linked-tryptamine-paeonol derivatives and evaluation of their selective inhibitions against butyrylcholinesterase and monoamine oxidase-B

Kang

Hwang

et al. 2022

International Journal of Biological Macromolecules

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Phosphonamidate Compounds for Butyrylcholinesterase Selective Inhibitors

Cited by 3 publications

References 36 publications

The Covalent Linking of Organophosphorus Heterocycles to Date Palm Wood-Derived Lignin: Hunting for New Materials with Flame-Retardant Potential

The Covalent Linking of Organophosphorus Heterocycles to Date Palm Wood-Derived Lignin: Hunting for New Materials with Flame-Retardant Potential

Metal‐Free Doubly Decarboxylative Three‐Component Reaction: Synthesis of Propargyl Amines

Synthesis of 4-substituted benzyl-2-triazole-linked-tryptamine-paeonol derivatives and evaluation of their selective inhibitions against butyrylcholinesterase and monoamine oxidase-B

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