Abstract:Protein kinase C (PKC)-mediated phosphorylation of α-tubulin
at Ser165 or expression of phosphomimetic (S165D)-α-tubulin
stimulates microtubule (MT) polymerization (Cytoskeleton
2014, 71, 257–272). Ser165
lies near the interface between adjacent αβ-tubulin heterodimers
and helix H8, which contains Glu254, the catalytic residue in α-tubulin
that hydrolyzes the exchangeable GTP in β-tubulin (β:GTP)
and triggers MT depolymerization. It was hypothesized that S165D,
a phosphomimetic variant of α-tubulin, perturbs t… Show more
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