Phospholipid-protein interaction as a determinant for the substrate specificity of mitochondrial nicotinamide-adenine-dinucleotide (phosphate) transhydrogenase

Pesch, Leroy A.; Peterson, J. Thomas

doi:10.1016/0005-2787(65)90559-9

Cited by 17 publications

(2 citation statements)

References 4 publications

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“…Lipase is reversibly adsorbed on the substrate surface, and bile salts enhance the rate of this reversible reaction (300). A change in the specificity of NADPH:NAD oxldoreductase of rat heart mitochondria has been noted upon treatment of the enzyme with phospholipase A or with lipid solvents (302). A number of polar lipids replace the naturally occurring ricinoleic acid tetramer.…”

Section: Lipid Functionsmentioning

confidence: 99%

“…Another lipase, the acid lipase of 2~icinus comrnunis, hydrolyzes long chain saturated glycerides in the presence of a cyclic tetramer of ricinoleic acid, but not after the enzyme has been extracted with butanol (301). In this instance the conformation of the enzyme may be changed by treatment (302). Since polar lipids are not required for the hydrolysis of water-soluble tributyrin, the lipid factor probably allows formation of a suitable enzyme-substrate complex.…”

Section: Lipid Functionsmentioning

confidence: 99%

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Lipid Metabolism

Olson¹

1966

Annu. Rev. Biochem.

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The malonyl-GoA pathway of the cytoplasm.-The synthesis of fatty acids in many living organisms is catalyzed by a cytoplasmic enzyme complex. These complexes, which contain at least six or seven different kinds of pro teins, are tightly bound together in yeast (1) and pigeon liver (2, 3) , but are readily dissociable in Clostridium kluyverii, E. coli (4), and in several plant systems (5, 6). Of the various fatty acid synthesizing complexes, the system from E. coli has been most extensively studied. Of predominant interest in these studies is the isolation and characterization of acyl carrier protein (ACP), which binds acyl intermediates during the formation of long chain fatty acids (1, 7, 8). ACP is heat stable, has 81 to 89 amino acids and con tains one free sulfhydryl group per mole, at which the acyl derivatives bind (9). ACP was first thought to contain cysteine (9), but later was shown to contain 2-mercaptoethylamine and an equivalent amount of fJ-alanine (10). These latter two compounds and pantoic acid are bound together as 4'-1 This review covers the period November 1964 through October 1965.2 Abbreviations used in formulae, or repeatedly in the text, are given below in alphabetical order: ACP (acyl carrier protein); ATPase (adenosine triph osphatase) ; CDP (cytidine diphosphate) ; CMP (cytidine monophosphate); DG (diglyceride); EFA (essential fatty acid) i FAD (flavin adenine dinucleotide) ; FM N (flavin mono nucleotide) i Gal (galactose) i GDP (guanosine dipho�phate); Gic (glucose); GTP (guanosine triphosphate) i Man (mannose) i MG (monoglyceride); GalNAc (N-acetyl galactosamine); GIcNAc (N -acetylglucosamine) i M urNAc (N-acetylmuramic add) i NAD (nicotinamide adenine dinucleotide) i NADH (reduced nicotinamide adenine dinucleotide) i NADP (nicotinamide adenine dinucleotide phosphate) ; NADPH (reduced nicotinamide adenine dinucleotide phosphate); NAN A (N -acetylneuraminic acid, sialic acid); OAA (oxaloacetic acid) i Pi (inorganic phosphate) i PG (prosta glandin) see Table II; PP (pyrophosphate); Pt.H, (2-amino-4-hydroxy-6-methyl tetrahydropteridine); PtJ -I.(rhamnose) ; sRNA (soluble ribonucleic acid); TCA (tricarboxylic acid cycle) i TDP (thymidine diphosphate); TG (triglyceride); UDP (uridine diphosphate). Fatty acids are often expressed in terms of the number of carbon atoms, number of double bonds and double bond position and isomer, e.g., linoleic acid is C18:2(9c, 12c), where c denotes cis and t indicates trans. R denotes the remaining portion of a given organic molecule which is not modified during the reaction shown. Amino acids are given con ventional three letter designations. R (rectus) and s (sinister) denote the absolute configuration of a carbon atom by the convention of Cahn, Ingold, & Prelog (1a).

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Section: Lipid Functionsmentioning

confidence: 99%

Section: Lipid Functionsmentioning

confidence: 99%

Lipid Metabolism

Olson¹

1966

Annu. Rev. Biochem.

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Lipid-Protein Interactions in the Structure of Biological Membranes

Lenaz

1972

Membrane Structure and Mechanisms of Biological Energy Transduction

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A comparative study of the phospholipids and fatty acids of some insects

Fast¹

1966

Lipids

127

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Phospholipids of 27 species of insects representing 6 orders and 20 families were examined by DEAE cellulose column chromatography to determine the choline/ethanolamine phosphoglyceride ratios, and by gas chromatography to determine the constituent fatty acids.The phosphorus in the ethanolamine phosphoglycerides accounted for approximately 50% of the total lipid phosphorus in aphids (Homoptera) and in all but one family of Diptera (flies) examined while the phosphorus in the choline phosphoglycerides accounted for only about 25%. Ethanolamine and choline phosphoglycerides were present in approximately equal proportions in one family of Diptera and in the Coleoptera (beetles) examined. In the other insects examined choline phosphoglycerides predominated, ethanolamine phosphoglycerides comprising only about 25-30% of total lipid phosphorus as they do in most mammalian tissues.Diptera in which ethanolamine phosphoglycerides were the major phosphatides were also characterized by high proportions of fatty acids less than 18 carbons long, particularly palmitoleic acid, in the neutral lipids. Aphids are characterized by a preponderance of 14-carbon fatty acids. The evidence suggests that predominance of ethanolamine phosphoglycerides is associated with a preponderance of shorter chain fatty acids in the neutral lipids.Differences also exist between Diptera and other insects in the fatty acid compositions of different phosphatides, particularly with respect to the distribution of 18-carbon acids. The compositions observed in insects that contained large amounts of the choline phosphoglycerides are similar to those found in vertebrates. Similarities in fatty acid composition of the choline phosphoglycerides in such widely divergent organisms suggest that the fatty acids may play a greater role in phospholipid function than has heretofore been demonstrated.

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Phospholipid-protein interaction as a determinant for the substrate specificity of mitochondrial nicotinamide-adenine-dinucleotide (phosphate) transhydrogenase

Cited by 17 publications

References 4 publications

Lipid Metabolism

Lipid Metabolism

Lipid-Protein Interactions in the Structure of Biological Membranes

A comparative study of the phospholipids and fatty acids of some insects

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