Phospholipid End‐Capped Acid‐Degradable Polyurethane Micelles for Intracellular Delivery of Cancer Therapeutics

John, Johnson V.; Thomas, Reju George; Lee, Hye Ri; Chen, Hongyu; Jeong, Yong Yeon; Kim, Il

doi:10.1002/adhm.201600126

Cited by 10 publications

(6 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Drug loading efficiency (DLE) was defined as DLE = mass of DOX loaded in FGC/mass of FGC@DOX × 100%. Drug loading content (DLC) was defined as DLC = mass of DOX loaded in FGC/mass of FGC × 100% …”

Section: Methodsmentioning

confidence: 99%

pH‐Responsive Nanoscale Coordination Polymer for Efficient Drug Delivery and Real‐Time Release Monitoring

Han

Zhang

et al. 2017

Adv Healthcare Materials

View full text Add to dashboard Cite

Both excess dosages of drug and unwanted drug carrier can lead to severe side effects as well as the failure of tumor therapy. Here, an Fe -gallic acid based drug delivery system is designed for efficient monitoring of drug release in tumor. Fe and polyphenol gallic acid can form polygonal nanoscale coordination polymer in aqueous solution, which exhibits certain antitumor effect. Importantly, this coordination polymer possesses extremely high doxorubicin (DOX) loading efficacy (up to 48.3%). In vitro studies demonstrate that the fluorescence of DOX can be quenched efficiently when DOX is loaded on the coordination polymer. The acidity in lysosome also triggers the release of DOX and fluorescence recovery simultaneously, which realizes real-time monitoring of drug release in tumor cells. In vivo studies further indicate that this polyphenol-rich drug delivery system can significantly inhibit tumor growth with negligible heart toxicity of DOX. This system with minimal side effects should be a promising nanoplatform for tumor treatment.

show abstract

Section: Methodsmentioning

confidence: 99%

pH‐Responsive Nanoscale Coordination Polymer for Efficient Drug Delivery and Real‐Time Release Monitoring

Han

Zhang

et al. 2017

Adv Healthcare Materials

View full text Add to dashboard Cite

show abstract

“…Doxorubicin-loaded phospholipid-linked polyurethane nanoparticles were prepared with acetal linkers, which were responsible for the particle degradation in acidic conditions. The molecular dynamics of these micelles revealed a compact core with surface-attached polymer chains and encapsulated doxorubicin (John et al, 2016). Doxorubicin-loaded polyethylene glycol (PEG) methyl ether-block-poly(ε-caprolactone) nanomicelles were prepared using different β-carboxylic amide amounts to improve the acid-labile properties of the polyester moieties (Deng et al, 2014).…”

Section: Internal Stimuli-responsive System Ph-responsive Systemmentioning

confidence: 99%

Tumor Microenvironment-Stimuli Responsive Nanoparticles for Anticancer Therapy

Thomas

Surendran

Jeong

2020

Front. Mol. Biosci.

Self Cite

View full text Add to dashboard Cite

Cancer is a disease that affects a large number of people all over the world. For treating cancer, nano-drug delivery system has been introduced recently with objective of increasing therapeutic efficiency of chemotherapeutic drug. The main characteristics of this system are the encapsulation of the insoluble chemotherapeutic cargo, increasing the period of circulation in the body, as well as the delivery of the drug at that specific site. Currently, the nano-drug delivery system based on the stimuli response is becoming more popular because of the extra features for controlling the drug release based on the internal atmosphere of cancer. This review provides a summary of different types of internal (pH, redox, enzyme, ROS, hypoxia) stimuli-responsive nanoparticle drug delivery systems as well as perspective for upcoming times.

show abstract

“…IR-820conjugated DCPE was prepared by coupling of aminocaproicacid-conjugated IR-820 dye with DCPE, as previously described. 40 The IR-820-conjugated SPE was formulated with DCPE-PU(SS)-DCPE lipopolymer via self-assembly (10/90 w/ w) to obtain fluorescent hybrid micelles via a simple heating and cooling method followed by dialysis and lyophilization. The synthetic pathway of the IR-820-loaded micelles and the fluoresence spectra of the material are shown in Figure S3.…”

Section: ■ Results and Discussionmentioning

confidence: 99%

Phospholipid End-Capped Bioreducible Polyurea Micelles as a Potential Platform for Intracellular Drug Delivery of Doxorubicin in Tumor Cells

John

Seo

Augustine

et al. 2016

ACS Biomater. Sci. Eng.

Self Cite

View full text Add to dashboard Cite

Bioreducible polymeric nanocarriers bearing disulfide bonds have been widely used for intracellular therapeutic delivery, since they are quickly sliced or reduced in the reductive milieu of cytosol. Incorporation of hydrophobic phospholipid analogues to polymers improves the biocompatibility by reducing the protein adsorption and platelet adhesion on the cell membranes. In this study, we have developed a series of bioreducible polyureas (PUs) bearing disulfide linkages in their backbone and phospholipid moieties in their chain ends. The reducible PUs exhibit interesting self-assembly behavior and controlled release profiles at intracellular mimic conditions. The self-assembled hybrid nanocarriers with an average diameter of about 110 nm efficiently encapsulated the model anticancer drug doxorubicin (Dox). The in vitro Dox release profile demonstrated a good glutathione (GSH)-responsive release of Dox at 10 mM GSH. An in vitro cell viability assay was also performed with various cell lines. The antitumor activity tests using HCT15 and HCT116 cancer cells showed that Dox-loaded nanocarriers bearing disulfide linkages induced significantly higher cytotoxicity in cancer cells than those without disulfide linkages. Hence, the PU nanocarriers bearing disulfide linkers and α,ω-phospholipid moieties have a promising potential to trigger the drug into the intracellular compartment of cancer cells.

show abstract

Phospholipid End‐Capped Acid‐Degradable Polyurethane Micelles for Intracellular Delivery of Cancer Therapeutics

Cited by 10 publications

References 27 publications

pH‐Responsive Nanoscale Coordination Polymer for Efficient Drug Delivery and Real‐Time Release Monitoring

pH‐Responsive Nanoscale Coordination Polymer for Efficient Drug Delivery and Real‐Time Release Monitoring

Tumor Microenvironment-Stimuli Responsive Nanoparticles for Anticancer Therapy

Phospholipid End-Capped Bioreducible Polyurea Micelles as a Potential Platform for Intracellular Drug Delivery of Doxorubicin in Tumor Cells

Contact Info

Product

Resources

About