Phospholipid complex-loaded self-assembled phytosomal soft nanoparticles: evidence of enhanced solubility, dissolution rate, ex vivo permeability, oral bioavailability, and antioxidant potential of mangiferin

Telange, Darshan R.; Sohail, Nazish K; Hemke, Atul T.; Kharkar, Prashant S.; Pethe, Anil M.

doi:10.1007/s13346-020-00822-4

Cited by 39 publications

(19 citation statements)

References 95 publications

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“…For drug delivery, nano-systems possessed the advantages of enhanced solubility (Telange et al 2021), improved stability (Hasanovic et al 2010), and controlled release (Qiu et al 2021) of the loaded drugs. They are widely reported in the literature for the therapy of local and systemic diseases, with encouraging in vitro and in vivo outcomes (Zhao and Liu 2018).…”

Section: Introductionmentioning

confidence: 99%

Unraveling the pulmonary drug delivery carriers in inhalable nanostructures

Huang

Wang

et al. 2022

J Nanopart Res

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were showcased. The bibliometric analysis of 3362 documents of interest indicated that most of the relevant source titles were in the fields of toxicology, pharmacy, and materials science. The three research hotspots were the biological process of inhalable nano-systems in vivo, the manufacture of inhalable nano-systems, and the impact of nano-systems on human health in the environment. Toxicity and safety have always been the keywords. The USA was the major contributing country, and international collaboration and co-authorship were common phenomena. The general situation and development trend of literature of inhalable nano-systems were summarized. It was anticipated that bibliometrics analysis could provide new ideas for the future research of inhalable nano-systems.

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Section: Introductionmentioning

confidence: 99%

Unraveling the pulmonary drug delivery carriers in inhalable nanostructures

Huang

Wang

et al. 2022

J Nanopart Res

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“…In that work, NLC were obtained combining glyceryl monosterate, Gelucire 44/14, Miglyol 812, Labrasol and large proportions of Tween 80 surfactant, but the antioxidant activity of MGN was not investigated. Other nanotechnological systems have been developed in order to increase the solubility and bioavailability of MGN, such as self-assembled phytosomal soft nanoparticles encapsulated with a phospholipid complex (MPLC SNPs) [28] and polymeric nanoparticles [29,30], demonstrating the importance of the nanoencapsulation strategy.…”

Section: Introductionmentioning

confidence: 99%

Design of Nanotechnological Carriers for Ocular Delivery of Mangiferin: Preformulation Study

et al. 2022

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(1) Background: Mangiferin (MGN) is a natural compound, showing anti-inflammatory and antioxidant activities for the potential treatment of eye diseases. The poor physicochemical features of MGN (low solubility and high instability) justify its nanoencapsulation into nanostructured lipid carriers (NLC) to improve its ocular bioavailability. (2) Methods: Firstly, MGN-NLC were prepared by the high shear homogenization coupled with the ultrasound (HSH−US) method. Finally, unloaded and MGN-loaded NLC were analyzed in terms of ocular tolerance. (3) Results: MGN-NLC showed good technological parameters suitable for ocular administration (particle size below 200 nm). The ORAC assay was performed to quantify the antioxidant activity of MGN, showing that the antioxidant activity of MGN-NLC (6494 ± 186 μM TE/g) was higher than that of the free compound (3521 ± 271 μM TE/g). This confirmed that the encapsulation of the drug was able to preserve and increase its activity. In ovo studies (HET-CAM) revealed that the formulation can be considered nonirritant. (4) Conclusions: Therefore, NLC systems are a promising approach for the ocular delivery of MGN.

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“…The self-assembled phytosomal soft nanoparticles (MPLC SNPs) containing phospholipid complexes were prepared by solvent evaporation and nanoprecipitation. 145 Compared to MGF, the aqueous solubility of MPLC SNPs is increased 39-fold, and the bioavailability is increased appreciably up to 10-fold. This surprising result proved that converting MGF into MPLC SNPs would greatly improve the shortcomings of MGF and give full play to its pharmacological effects.…”

Section: Mangiferin: Dosage and Applicationmentioning

confidence: 99%