Phospholipid-based reverse micelles

Walde, Peter; Giuliani, Anna Maria; Boicelli, C. A.; Luisi, Pier Luigi

doi:10.1016/0009-3084(90)90026-n

Cited by 111 publications

(77 citation statements)

References 97 publications

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“…The transfer into jelly-like state has been demonstrated only for nonaqueous solutions of naturally occurring unsaturated lecithins. 23,26 The latter are mainly separated from soy bean and egg yolk. Lecithin is a trivial name for 1, 2-diacyl-sn-3-phosphocholine.…”

Section: Organogel Compositionmentioning

confidence: 99%

“…[22][23][24]26 Chemical stability LOs are moisture insensitive, and being organic in character, they also resist microbial contamination. 20,21,26 Topical delivery potential…”

Section: Structural/physical Stabilitymentioning

confidence: 99%

“…The molecules of polar solvent, on addition, bind in stoichiometric ratios to the hydrophilic head portion of the lecithin molecules in such a way that 2 adjacent lecithin molecules are bridged together by 1 polar molecule. 23,30 This leads to the formation of linear networks, from hydrogen bonds formed by the polar molecules and phosphate groups of 21 lecithin molecules and, in turn, to the 1-dimensional uniaxial growth of lecithin reverse micelles. Further increase in the amount of polar additive results in the formation of flexible, long tubular micelles of 2.0 to 2.5 nm radius and hundreds to thousands of nanometers in length.…”

Section: Organogel Structure and Mechanism Of Organogellingmentioning

confidence: 99%

“…77,78 For the determination of PTTs, hot stage microscopy (HSM) and high sensitivity differential scanning calorimetry (HSDSC) have been reported to be useful as accurate and sensitive techniques. 21,23,77 However, the inverse flow method, a simple technique based on visual observations has also been employed. 79 …”

Section: Phase Transition Temperaturesmentioning

confidence: 99%

“…22 The formation of a 3-dimensional network in the organogel is the result of transition at the micellar level in a low viscous Newtonian liquid consisting of lecithin reverse micelles in nonpolar organic liquid. 23,24 This spherical reverse micellar state of lipid aggregates turns on to form elongated tubular micelles with the addition of water and subsequently entangles to form a temporal 3-dimensional network in the solution bulk. 22,[24][25][26] The latter serves to immobilize the external organic phase, thus producing a gel form or the jelly-like state of the initial nonviscous solution.…”

Section: Introductionmentioning

confidence: 99%

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Lecithin organogels as a potential phospholipid-structured system for topical drug delivery: A review

2005

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The purpose of this review is to give an insight into the considerable potential of lecithin organogels (LOs) in the applications meant for topical drug delivery. LOs are clear, thermodynamically stable, viscoelastic, and biocompatible jelly-like phases, chiefly composed of hydrated phospholipids and appropriate organic liquid. These systems are currently of interest to the pharmaceutical scientist because of their structural and functional benefits. Several therapeutic agents have been formulated as LOs for their facilitated transport through topical route (for dermal or transdermal effect), with some very encouraging results. The improved topical drug delivery has mainly been attributed to the biphasic drug solubility, the desired drug partitioning, and the modification of skin barrier function by the organogel components. Being thermodynamically stable, LOs are prepared by spontaneous emulsification and therefore possess prolonged shelf life. The utility of this novel matrix as a topical vehicle has further increased owing to its very low skin irritancy potential. Varied aspects of LOs viz formation, composition, phase behavior, and characterization have been elaborated, including a general discussion on the developmental background. Besides a comprehensive update on the topical applications of lecithin organogels, the review also includes a detailed account on the mechanistics of organogelling.

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Section: Organogel Compositionmentioning

confidence: 99%

“…[22][23][24]26 Chemical stability LOs are moisture insensitive, and being organic in character, they also resist microbial contamination. 20,21,26 Topical delivery potential…”

Section: Structural/physical Stabilitymentioning

confidence: 99%