Phospholipase enzymes as potential biomarker for SARS CoV-2 virus

Hemalika, D. V. Dayangi

doi:10.29322/ijsrp.11.01.2021.p10919

Cited by 6 publications

(6 citation statements)

References 43 publications

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“…Будучи незамінною речовиною для структурних фосфоліпідів клітинних мембран, цитиколін чинить нейропротекторну дію на пацієнтів із неврологічними захворюваннями [26][27][28].…”

Section: вступunclassified

“…Щодо протизапальної та нейропротекторної дій цитиколіну, то нещодавні дослідження виявили кореляцію між роллю фосфоліпази А2 у каскаді запалення COVID-19 і виникненням цитокінового шторму [28]. Цитиколін може послабити підвищення активності фосфоліпази A2, будучи джерелом холіну для запобігання гідролізу фосфоліпідів, коли внутрішні рівні холіну виснажуються.…”

Section: результати та їх обговоренняunclassified

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Possibility of correction of cerebral blood flow disorders and central nervous system damage with citicoline in patients with coronary artery disease in combination with COVID-19

Netiazhenko,

Mostovyi

2024

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ABSTRACT. The review describes some pathogenetic mechanisms of central nervous system lesions in patients with coronary artery disease in combination with coronavirus disease (COVID-19) and presents the current possibilities of their pharmacotherapy. The analysis of experimental and clinical trials has shown that the multifactorial effect of citicoline on the main pathogenic links of brain damage in COVID-19 and numerous positive clinical effects make it a promising drug in the treatment of patients with coronary artery disease in combination with COVID-19 and post-COVID syndrome.

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Section: вступunclassified

Section: результати та їх обговоренняunclassified

Possibility of correction of cerebral blood flow disorders and central nervous system damage with citicoline in patients with coronary artery disease in combination with COVID-19

Netiazhenko,

Mostovyi

2024

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“…Цитиколін є інгібітором фосфоліпаз (А1, А2, С і D), що здатний зменшувати утворення вільних радикалів і запобігає руйнуванню мембранних систем, а також зберігає антиоксидантні захисні системи -глутатіон. Цитиколін зберігає запас аденозинтрифосфату (АТФ) нейронів завдяки мітохондріальнопротекторному ефекту, інгібує апоптоз нейронів і стимулює синтез ацетилхоліну [7][8][9], має протизапальний, антиішемічний ефекти, а також противірусну дію щодо COVID-19.…”

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The role of citicoline in the correction of cerebral blood flow disorders in patients with coronary artery disease in combination with COVID-19

Netiazhenko,

Mostovyi

2024

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OBJECTIVE. To evaluate the effect of citicoline on cerebral blood flow and microembolic signals (MES) after 6 months of treatment in patients with coronary artery disease combined with coronavirus disease (COVID-19). MATERIALS AND METHODS. A prospective study of 68 patients with coronary artery disease with confirmed COVID-19 by PCR was conducted. Group I (n=35) included patients with coronary artery disease in combination with COVID-19, who, in addition to standard therapy of cerebrovascular disease, received citicoline (500 mg twice daily) for 6 months after discharge from the hospital. The comparison group (group II; n=33) consisted of patients who did not receive citicoline. Cerebral blood flow, peak systolic velocity in extracranial and intracranial vessels were determined, and 1-hour transcranial monitoring to detect MES were performed. Patients were re-examined in 6 months. RESULTS. At the initial examination of patients, cerebral blood flow and the number of MES did not differ significantly. After 6 months, there was an increase in cerebral blood flow in the cerebral arteries, as well as a decrease in MES in patients taking citicoline, whereas in group II there was no positive dynamics of this ratio. A direct correlation between plasma C-reactive protein, D-dimer and MES was found in patients of both groups. After 6 months of treatment, C-reactive protein and D-dimer decreased in both groups equally. CONCLUSIONS. The obtained results of improvement of cerebral perfusion, blood rheology, due to the anti-inflammatory effect, stabilising function of citicoline on phospholipid membranes of cerebral vascular endothelium, neurons and glial elements allow the use of citicoline in patients with coronary artery disease in combination with COVID-19 to reduce the negative impact of COVID-19 on the central nervous system.

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“…He emphasized the Sars CoV-2 upregulation of the LpPLA2 enzyme in the production of inflammatory fatty acids and subsequent over production of ROS. CDP choline provided a negative feedback/partial blockade of the PLA2 enzyme [35][36][37].…”

Section: Wave Twomentioning

confidence: 99%

Intravenous high dose vitamin C and ozonated saline effective treatment for Covid -19: The Evolution of Local Standard of Care

Viglione¹,

Thorp²

2023

G Med Sci

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An effective protocol for COVID-19 treatment was started at an internal medicine clinic in Gulf Breeze, FL and began with a local group of physicians using best practices from review of all the literature including the Sars CoV-1 at the turn of this century. There are limited studies on the early outpatient treatment of COVID-19 using intravenous-ozonated saline. The purpose of this report is to describe our experience.

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Phospholipase enzymes as potential biomarker for SARS CoV-2 virus

Cited by 6 publications

References 43 publications

Possibility of correction of cerebral blood flow disorders and central nervous system damage with citicoline in patients with coronary artery disease in combination with COVID-19

Possibility of correction of cerebral blood flow disorders and central nervous system damage with citicoline in patients with coronary artery disease in combination with COVID-19

The role of citicoline in the correction of cerebral blood flow disorders in patients with coronary artery disease in combination with COVID-19

Intravenous high dose vitamin C and ozonated saline effective treatment for Covid -19: The Evolution of Local Standard of Care

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