Phospholipase C Epsilon 1 (PLCE1 rs2274223A&gt;G, rs3765524C&gt;T and rs7922612C&gt;T) Polymorphisms and Esophageal Cancer Risk in the Kashmir Valley

Malik, Manzoor Ahmad; Umar, Meenakshi; Gupta, Urvashi; Zargar, Showkat Ali; Mittal, Balraj

doi:10.7314/apjcp.2014.15.10.4319

Cited by 16 publications

(9 citation statements)

References 24 publications

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“…At present, esophageal cancer ranks the 8th of the incidence of malignant tumors all over the world and patients with esophageal cancer in China takes up more than 50% of the world, with the mobility and cancer related mortality ranking the 4th, highly occurring in Lin County and Anyang City, Hennan Province (Yuan et al, 2014;Malik et al, 2014;Yang et al, 2014;Somi et al, 2014;Zheng et al, 2014). About 50% of patients were found with the advanced period of esophageal cancer when diagnosed, with unfavorable prognosis, about 6~8 months of natural course, 5%~7% five-year survival rate (; Liu et al, 2014;Mai et al, 2014;Zhao et al, 2014;Jiang et al, 2014;Wang et al, 2014;Stefani et al, 2014).…”

Section: Discussionmentioning

confidence: 99%

Clinical Observation and Therapeutic Evaluation of Rh-endostatin Combined with DP Regimen in Treating Patients with Advanced Esophageal Cancer

Deng

Song²,

Li³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Objective: To observe the curative effects of rh-endostatin combined with DP regimen in treating patients with advanced esophageal cancer and analyze the correlation of CT perfusion (CTP) parameters and the expression of vascular endothelial growth factor (VEGF). Methods: Twenty patients with esophageal cancer confirmed pathologically were randomly divided into combined treatment (rh-endostatin+DP regimen) group and single chemotherapy group, 10 patients in each group, respectively. All patients were given conventional CT examination and CTP imaging for primary tumor. The level of VEGF, the size of tumor and CTP parameters (BF, BV, PS and MTT) before treatment and after 2 cycles of treatment were determined for the comparison and the correlation between CTP parameters and VEGF expression was analyzed. Results: the therapeutic effect of rh-endostatin+DP regimen group was superior to single chemotherapy group. VEGF level after treatment in rhendostatin +DP regimen group was obviously lower than single chemotherapy group (P<0.01). The expression of VEGF had positive correlation with BF and BV but negative correlation with MTT. Compared with treatment before for rh-endostatin +DP regimen group, BF, BV and PS decreased while MTT increased after treatment (P<0.05). However, there were no significant differences between treatment before and after treatment in single chemotherapy (P>0.05). Conclusions: Rh-endostatin can down-regulate the expression of VEGF in esophageal cancer, change the state of hypertransfusion and high permeability of tumor vessels and had the better curative effect and slighter adverse reactions when combined with chemotherapy.

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Section: Discussionmentioning

confidence: 99%

Clinical Observation and Therapeutic Evaluation of Rh-endostatin Combined with DP Regimen in Treating Patients with Advanced Esophageal Cancer

Deng

Song²,

Li³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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“…This phospholipase has been reportedly associated with intracellular signaling through the regulation of a variety of proteins, such as the protein kinase C (PKC) isozymes and the proto-oncogene ras (Rhee, 2001;Bunney et al, 2009). Also replicated independent studies have validated the association of PLCE1 polymorphism with esophageal cancer in Chinese Kazakh and Kashmiri population Malik et al, 2014). Recent studies have shown that, increased PLCE1 expression is related to the development of bladder cancer (Ou et al, 2010).…”

Section: Introductionmentioning

confidence: 94%

Prognostic Value of PLCE1 Expression in Upper Gastrointestinal Cancer: a Systematic Review and Meta-analysis

Cui

Peng²,

Su³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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“…A genome-wide association pathway analysis found that rs3765524 contributed to GC susceptibility [81, 82], while a case-control study of the Chinese population showed that rs3765524 was associated with disease risk in GC and ESCC [58, 67, 83]. Investigations of South Asian patients showed similar results for GC [72] but not for ESCC [78, 84]. Additionally, a recent meta-analysis showed that like rs2274223, rs3765524 was significantly associated with disease risk [79].…”

Section: Discussionmentioning

confidence: 99%

PLCE1 polymorphisms and expression combined with serum AFP level predicts survival of HBV-related hepatocellular carcinoma patients after hepatectomy

et al. 2017

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Polymorphisms in the phospholipase C epsilon (PLCE) 1 gene play a crucial role in the development and progression of several types of cancer. The present study investigated the prognostic significance of PLCE1 gene polymorphisms and expression combined with serum α-fetoprotein (AFP) level in hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC). Single nucleotide polymorphisms were genotyped by sequencing DNA isolated from surgically resected tumor samples of 421 HBV-related HCC patients, and expression profiles were generated based on the GSE14520 dataset. A joint-effects analysis of PLCE1 haplotypes (Ars2274223Crs3765524; Grs2274223Trs3765524) with AFP level stratified at 20 ng/ml showed a significant association with overall survival(OS) of HBV-related HCC patients(log-rank P=0.0003). Patients with AC and GT haplotypes with AFP level ≥ 20 ng/ml had an increased risk of death as compared to those with the AC haplotype and AFP level < 20 ng/ml (adjusted P=0.029 and 0.041, respectively). Patients with the GT haplotype and AFP level < 20 ng/ml also had an increased risk of death, although with a non-significant P value (adjusted P=0.092). Joint-effects analysis of PLCE1 mRNA expression with serum AFP level stratified at 300 ng/ml was significantly associated with HBV-related HCC recurrence and OS. Our results demonstrate that PLCE1 haplotypes (including rs2274223 and rs3765524) and expression combined with serum AFP level may predict postoperative outcome of HBV-related HCC patients.

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Phospholipase C Epsilon 1 (PLCE1 rs2274223A>G, rs3765524C>T and rs7922612C>T) Polymorphisms and Esophageal Cancer Risk in the Kashmir Valley

Cited by 16 publications

References 24 publications

Clinical Observation and Therapeutic Evaluation of Rh-endostatin Combined with DP Regimen in Treating Patients with Advanced Esophageal Cancer

Clinical Observation and Therapeutic Evaluation of Rh-endostatin Combined with DP Regimen in Treating Patients with Advanced Esophageal Cancer

Prognostic Value of PLCE1 Expression in Upper Gastrointestinal Cancer: a Systematic Review and Meta-analysis

PLCE1 polymorphisms and expression combined with serum AFP level predicts survival of HBV-related hepatocellular carcinoma patients after hepatectomy

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