2015
DOI: 10.1016/j.bbalip.2014.09.014
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Phosphoinositides in endocytosis

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Cited by 150 publications
(186 citation statements)
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References 155 publications
(235 reference statements)
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“…This conversion is assured by the spatio-temporally controlled, sequential action of PI-kinases and -phosphatases and recruitment of PI-specific adaptor complexes (Posor, Eichhorn-Grunig et al 2015).…”
Section: Pi(45)p 2 -To-pi(3)p Conversion In Endocytic Membrane Trafficmentioning
confidence: 99%
See 2 more Smart Citations
“…This conversion is assured by the spatio-temporally controlled, sequential action of PI-kinases and -phosphatases and recruitment of PI-specific adaptor complexes (Posor, Eichhorn-Grunig et al 2015).…”
Section: Pi(45)p 2 -To-pi(3)p Conversion In Endocytic Membrane Trafficmentioning
confidence: 99%
“…4'-and 5'-dephosphorylation of PI(4,5)P 2 by synaptojanin (Verstreken, Koh et al 2003) or the oculocerebrorenal syndrome of Lowe (OCRL) (Nandez, Balkin et al 2014) favours dissociation of AP-2 and disassembly of the clathrin coat. Further, the PI(3,4)P 2 -specific inositol-4-phosphatase INPP4B, an early endosomal Rab5 effector, might be required for PI(3,4)P 2 -removal from CCVs and thereby adds to generation of the early endosomal PI(3)P pool (Shin, Hayashi et al 2005;Posor, Eichhorn-Grunig et al 2015). These steps thus help to restrict PI(4,5)P 2 and PI(3,4)P 2 to the plasma membrane (Erdmann, Mao et al 2007).…”
Section: Pi(45)p 2 -To-pi(3)p Conversion In Endocytic Membrane Trafficmentioning
confidence: 99%
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“…Conversely, some evidence suggests this relationship works in the opposite direction; F-BAR proteins may serve to cluster certain plasma membrane lipids into stable micro-domains. 24 F-BAR domain-mediated clustering of lipids could be important for generating distinct lipid environments at cellular structures like endocytic sites, 25 caveolae, 26 or neuronal spines. 27 This hypothesis requires further investigation in vivo, perhaps with specific lipid sensors to assay for lipid organization defects in F-BAR membrane-binding mutants.…”
Section: Membrane Bindingmentioning
confidence: 99%
“…It is worth noting here that during clathrin-dependent endocytosis, the auto-inhibitory conformation of WASL can be altered upon interaction with both CDC42 and PtdIns(4,5)P 2 , which cause actin assembly at the surface of the plasma membrane that has high PtdIns(4,5)P 2 levels. 18 Unfortunately it is unknown if WHAMM and JMY are activated by PtdIns3P, just as WASL is activated by PtdIns(4,5)P 2 .…”
mentioning
confidence: 99%