“…The known relationship(s) between phosphoinositide signaling and membrane transport are widespread and complex, involving highly regulated inositol-1,4,5-trisphosphate-and inositol-1,4,5-tetrakisphosphate-mediated intracellular (40, 41) and transplasmalemmal (40) calcium fluxes, and diacyl-glycerol-mediated stimulation of phospholipid-and-calcium-dependent protein kinase C (39). Protein kinase C agonists affect growth and differentiation in some cells, and have multiple effects on membrane transport such as the induction of the glucose transporter gene (42).…”