2021
DOI: 10.3389/fcell.2021.690461
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Phosphoinositide Recognition Sites Are Blocked by Metabolite Attachment

Abstract: Membrane readers take part in trafficking and signaling processes by localizing proteins to organelle surfaces and transducing molecular information. They accomplish this by engaging phosphoinositides (PIs), a class of lipid molecules which are found in different proportions in various cellular membranes. The prototypes are the PX domains, which exhibit a range of specificities for PIs. Our meta-analysis indicates that recognition of membranes by PX domains is specifically controlled by modification of lysine … Show more

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Cited by 8 publications
(2 citation statements)
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“…Sequence analysis revealed a PX domain PI-binding structural module at the N-terminal half of this protein, confirming its initial classification as a phosphoinositide-binding protein [42]. PX domain-containing proteins are candidate PI effectors with roles in the PI regulatory network involved in fundamental processes for the life of eukaryotes [17,56,57], while all members of the SNX family contain at least one PX domain [2]. The LdBPK_352470 gene encodes a protein of 417 a.a. residues (predicted MW 46.6 kDa) and is registered in UniProt under the identifier A0A504X805.…”
Section: Discussionmentioning
confidence: 62%
“…Sequence analysis revealed a PX domain PI-binding structural module at the N-terminal half of this protein, confirming its initial classification as a phosphoinositide-binding protein [42]. PX domain-containing proteins are candidate PI effectors with roles in the PI regulatory network involved in fundamental processes for the life of eukaryotes [17,56,57], while all members of the SNX family contain at least one PX domain [2]. The LdBPK_352470 gene encodes a protein of 417 a.a. residues (predicted MW 46.6 kDa) and is registered in UniProt under the identifier A0A504X805.…”
Section: Discussionmentioning
confidence: 62%
“… Lomize, Todd, and Pogozheva, 2022 ). The regulatory impact of small modifications is generally limited to distances corresponding to ∼5 residues, as these bounds were previously useful for identifying positions that, when phosphorylated or metabolite-modified, modulate specific membrane recognition by protein residues acting as PIP-stops ( Kervin and Overduin, 2021 ) and MET-stops majority of membrane binding ( Kervin et al, 2021 ).…”
Section: Methodsmentioning
confidence: 99%