Abstract:SUPPLEMENTARY NOTESReport contains color Extensive studies have demonstrated that the Akt pathway is essential for cell survival and anti-apoptosis; however, alterations of Akt in human malignancy have not been documented. We have recently demonstrated significantly increased AKT1 and AKT2 kinase activity in primary ovarian carcinomas. We have also shown that PI3K is frequently activated in the specimens with activation of Akt. The majority of cases with PI3K/Akt activation are late stage and high grade. The b… Show more
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