Phosphodiesterases S-sulfhydration contributes to human skeletal muscle function.

Vellecco, Valentina; Panza, Elisabetta; Bibli, Sofia-Iris; Casillo, Gian Marco; Raucci, Federica; Manzo, Onorina Laura; Smimmo, Martina; Villani, Romolo; Cavezza, Maria Rosaria; Fleming, Ingrid; Bianca, Roberta d’Emmanuele di Villa; Maione, Francesco; Cirino, Giuseppe; Bucci, Mariarosaria

doi:10.1016/j.phrs.2022.106108

Cited by 10 publications

(1 citation statement)

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“…Concerning the mechanisms of action, the pleiotropic effects of H 2 S mainly result from the change in the structure and activity of target proteins following S‐persulfidation of cysteine residues (Filipovic, 2015; Piragine et al, 2022; Vellecco et al, 2022; Zhang et al, 2017). Effects range from antioxidant actions, through the ability to enhance the antioxidant endogenous machinery via activation of the Nrf2/Keap1/ARE pathway (Corsello et al, 2018), to vasorelaxant actions, due to the opening of sarcolemmal potassium channels and to a series of less documented but crucial mechanisms (i.e., inhibition of phosphodiesterase‐5A (PDE‐5A); activation of vascular endothelial growth factor receptor‐2 (VEGFR‐2); cross‐talk with the gasotransmitter nitric oxide (NO) (Piragine et al, 2022).…”

Section: Hydrogen Sulfidementioning

confidence: 99%

Hydrogen sulfide and epigenetics: Novel insights into the cardiovascular effects of this gasotransmitter

Spezzini

Piragine

Bianca

et al. 2023

British J Pharmacology

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Epigenetics studies the heritable modifications of genome expression that do not affect the nucleotide sequence. Epigenetic modifications can be divided into: DNA methylation, histone modifications, and modulation of genome expression by non‐coding RNAs. Alteration of these mechanisms can alter the phenotype, and can lead to disease onset. The endogenous gasotransmitter hydrogen sulfide (H2S) plays pleiotropic roles in many systems, including the cardiovascular (CV) system, and its mechanism of action mainly includes S‐persulfidation of cysteine residues. Recent evidence suggests that many H2S‐mediated biological activities are based on the epigenetic regulation of cellular function, with effects ranging from DNA methylation to modification of histones and regulation of non‐coding RNAs. This review describes the role of H2S‐regulating epigenetic mechanisms, providing a panorama of the current literature, and offers a novel scenario for the development of H2S‐releasing ‘epidrugs’ with a potential clinical use in the prevention and treatment of many CV and non‐CV disorders.

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