Phosphodiesterase type 5 inhibitors’ extended duration of response as a variable in the treatment of erectile dysfunction

Dunn, Marian E.; Althof, Stanley E.; Perelman, Michael A.

doi:10.1038/sj.ijir.3901490

Cited by 27 publications

(14 citation statements)

References 35 publications

(44 reference statements)

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“…All the three drugs have similar efficacy and toxicity profiles following oral administration [6]. Regarding their side effects, headache, facial flushing, blurred vision, nasal congestion, dyspepsia and musculoskeletal pain have been observed as the most common adverse events [7][8][9][10].…”

Section: Introductionmentioning

confidence: 99%

Development and validation of a gas chromatography‐mass spectrometric method for the determination of sildenafil and desmethyl‐sildenafil in whole blood

Papoutsis

Νικολάου

Athanaselis

et al. 2011

J of Separation Science

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Sildenafil (SDL) is a phosphodiesterase type 5 inhibitor and it is approved for the treatment of erectile dysfunction and pulmonary hypertension. SDL is extensively metabolized to its pharmacologically active metabolite, desmethyl-sildenafil (DSDL). A sensitive and specific GC/MS method for the determination of SDL and DSDL in whole blood was developed and validated to support therapeutic drug monitoring of SDL patients. The combination of solid-phase extraction with derivatization using BSTFA with 1% TMCS in acetonitrile efficiently reduced matrix effect and improved sensitivity of the method. In this assay, protriptyline was used as internal standard for both analytes. The LODs were 1.50 and 5.00 ng/mL for SDL and DSDL, respectively, whereas the respective LOQs were 5.00 and 15.0 ng/mL. The calibration curves were linear up to 500.0 ng/mL (SDL: R(2) 0.992, DSDL: R(2) 0.990). Absolute recovery values for both analytes ranged from 83.1 to 93.2%. Within- and between-batch accuracy was less than 11.8 and 10.2%, respectively, whereas within- and between-batch precision was less than 8.1 and 10.8%, correspondingly. The developed method is suitable for the determination of SDL and DSDL concentrations in blood samples obtained from patients under Viagra(®) treatment, for pharmacokinetic studies or for the investigation of related forensic cases.

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Section: Introductionmentioning

confidence: 99%

Development and validation of a gas chromatography‐mass spectrometric method for the determination of sildenafil and desmethyl‐sildenafil in whole blood

Papoutsis

Νικολάου

Athanaselis

et al. 2011

J of Separation Science

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“…The therapy has been proven effective in ED caused by different pathogenetic mechanisms, for example, in diabetes, post-prostatectomy, age-related vascular insufficiency, drug-induced impairment, etc. [4,[73][74][75][76][77][78][79][80].…”

Section: Men (Biomedical Interventions)mentioning

confidence: 99%

“…The different characteristics with respect to onset of effect and duration of effect can be used in therapeutic decision making according to the needs and wishes of the man and the couple [80].…”

Section: Men (Biomedical Interventions)mentioning

confidence: 99%

Sexual Counseling in Elderly Couples

Bitzer

Platano²,

Tschudin

et al. 2008

The Journal of Sexual Medicine

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Introduction Sexual health of the elderly has long been either a taboo or a non-medical life style luxury issue. Increasing longevity of women and men, reconceptualization of sexual health as part of general health, and the development of drugs aiming at improvement of sexual function have contributed to a change in the attitude of the elderly and the medical community, thus increasing the demands for help. Aims To respond to these demands, caregivers need to be informed about the statistics concerning the sex life of the elderly, need to understand the biological, psychological, interaction and social factors that determine the sexual health of the aging population, need a comprehensive diagnostic and therapeutic approach, taking into account the specific characteristics of the aging male, female, and the couple. Main Outcome Measures Diagnostic and therapeutic algorithm integrating the biopsychosocial profile of the aging male and female and the interaction characteristics of the couple. Methods Review of the literature, analysis of cases, and review of multidisciplinary case discussions of elderly couples with sexual problems consulting the Division of Sexual Medicine at the University Hospital of Basel. Results Sexual dysfunction is highly prevalent in the aging population, with hypoactive sexual desire disorder and pain disorders being the most frequent in women, and premature ejaculation and erectile dysfunction being the most frequent in men. The specific characteristics of the sexual ill health in elderly couples are the interactions of physical and mental morbidity including therapies, multidimensional sexual dysfunctions in both partners, dyssynchrony in personal development and sexual scripts, and a longstanding fixed interactional pattern with rigid “sexual roles.” The diagnostic approach has to integrate sexological descriptive diagnoses of both partners, their biopsychosocial profile, and the couple's history and interactional pattern. From this diagnostic framework, caregivers must design specific, multidisciplinary therapeutic strategies for the elderly couple, which include biomedical, individual psychotherapeutic, and systemic interventions in various combinations. Conclusion The increasing demand for help of elderly couples with sexual dysfunction requires a multidisciplinary approach in diagnosis and therapy combining the knowledge and skills of urologists, gynecologists, internists, and various mental health professionals to provide individualized age-related care.

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“…Of note, PDE5is only work with sexual stimulation, as this generates 3′5′-cGMP. Thus, becoming aware of the patient and partner's sexual script will often be useful in determining both choice of medication and dosing strategy used [100]. …”

Section: Introductionmentioning

confidence: 99%

Current Diagnosis and Management of Erectile Dysfunction

Pastuszak

2014

Curr Sex Health Rep

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Erectile dysfunction (ED) affects a growing number of men in the USA and abroad, with significant impacts on sexual function and overall quality of life. The risk factors for ED are numerous and include a strong link to cardiovascular disease, such that men with ED should be screened for cardiovascular disease. The evaluation of men presenting with ED includes a comprehensive history and physical exam to aid in the identification of comorbidities as well as laboratory testing to evaluate hormone and lipid levels and sugar metabolism. Adjunct studies are also available, though their utility is often limited to specific subtypes of ED. Once the etiology of ED is established, treatment can be initiated using appropriate medical therapies, including phosphodiesterase type 5 (PDE5) inhibitors, and transurethral or intracavernosal therapies, with surgical intervention via revascularization or penile prosthesis placement in men demonstrating a lack of response to medical therapy. In all cases of ED, a psychogenic component is present and referral for psychological intervention with or without medical therapy should be considered.

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Phosphodiesterase type 5 inhibitors’ extended duration of response as a variable in the treatment of erectile dysfunction

Cited by 27 publications

References 35 publications

Development and validation of a gas chromatography‐mass spectrometric method for the determination of sildenafil and desmethyl‐sildenafil in whole blood

Development and validation of a gas chromatography‐mass spectrometric method for the determination of sildenafil and desmethyl‐sildenafil in whole blood

Sexual Counseling in Elderly Couples

Current Diagnosis and Management of Erectile Dysfunction

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