Abstract:Our previous studies have shown that IWS1 (Interacts with Spt6) is a phosphorylation target of AKT and regulates the alternative RNA splicing of FGFR-2, linking IWS1 with lung cancer tumorigenesis. To further address the role of IWS1 in alternative RNA splicing and lung cancer, we performed an RNA-seq study using lung adenocarcinoma cells in which IWS1 was knocked down or replaced by its phosphorylation site mutant. The results identified a novel splice variant of the splicing factor U2 Associated-Factor 2 (U2… Show more
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