Phosphine-induced oxidative damage in rats: role of glutathione

Hsu, Ching Hung; Ching, Bei; Liu, Ming Yie; Li, Jih Heng; Chen, Chiou-Jong; Chen, Ruey Yu

doi:10.1016/s0300-483x(02)00246-9

Cited by 118 publications

(85 citation statements)

References 37 publications

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“…On the other hand, in these patients the phosphine gas is combined with oxygen and creates phosphoric acid. Another factor causing acidosis is the reduced number or depth of breathing that while increasing the arterial PaCO 2 causes respiratory acidosis [14,15]. Also in another article Singh Bumbrah et al reported that respiratory acidosis or alkalosis can accrue in patients [16].…”

Section: Discussionmentioning

confidence: 99%

Study of laboratory profile in patients with aluminium phosphide poisoning in the southwest of Iran from 2010 to 2015

Jamshidi¹,

Ghorbani²,

Darvishi³

et al. 2016

amsik

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StreszczenieWstęp: Fosforek glinu, określany w Iranie jako "tabletka ryżowa" ze względu na stosowanie w ochronie upraw ryżu, jest jednym z najczęściej stosowanych pestycydów na świecie. W kontakcie z wodą, parą lub kwasem żołądkowym uwalnia gaz -fosforowodór, co może wywoływać zatrucie. Zatrucie fosforowodorem jest często stosowaną metodą samobójstwa, a liczba takich przypadków stale rośnie. W dwóch trzecich przypadków zatrucie fosforowodorem ma skutek śmiertelny. Celem badania była ocena danych dotyczących epidemiologii klinicznej oraz zmian parametrów laboratoryjnych u pacjentów po zatruciu "tabletką ryżową". Materiały i metody: W badaniu uwzględniono łącznie 23 pacjentów z zatruciem fosforkiem glinu hospitalizowanych w szpitalu Razi w mieście Ahwaz w latach 2010-2015. Dane analizowano przy użyciu metod statystyki opisowej oraz testów statystycznych. Wyniki: Średni wiek pacjentów wynosił 27,2 ±7,3 roku. Mężczyźni stanowili 60,9% analizowanej grupy pacjentów. U 8,7% pacjentów stwierdzono hiponatremię, a u 21,7% -hipokaliemię. W większości przypadków poziom sodu i potasu mieścił się w granicach normy. U 91% pacjentów występowała kwasica. W większości przypadków stwierdzano także obniżenie poziomu wodorowęglanów w surowicy. Średni okres od zatrucia do hospitalizacji wynosił 1,48 ±0,76 godzin. Wnioski: Przebieg zmian w poziomie elektrolitów i innych parametrów laboratoryjnych może być dobrym markerem ciężkości zatrucia oraz stanu klinicznego pacjenta. Niezbędne są dodatkowe badania w celu potwierdzenia powyższej zależności.Słowa kluczowe: fosforek glinu, tabletki ryżowe, pestycydy, zatrucie. AbstractIntroduction: Aluminium phosphide or rice tablet is one of the most common pesticides around the world. The substance releases phosphine gas in the presence of water, steam or stomach acid which can lead to poisoning. Phosphine poisoning is more about suicide the number of which is increasing day by day. Two-thirds of patients lose their lives. The aim of this study was to evaluate the data on the clinical epidemiology and laboratory changes in patients poisoned with rice tablets.

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Section: Discussionmentioning

confidence: 99%

Study of laboratory profile in patients with aluminium phosphide poisoning in the southwest of Iran from 2010 to 2015

Jamshidi¹,

Ghorbani²,

Darvishi³

et al. 2016

amsik

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“…In rats, Hsu et al (2002) (29) examined the production of reactive oxygen species, lipid peroxidation and the effectiveness of endogenous glutathione (GSH) as a protective agent against phosphine-induced oxidative damage. They found that phosphine significantly decreased GSH, GSH peroxidase and catalase, while significantly increased lipid peroxidation, DNA oxidation (as 8-hydroxydeoxyguaonsoine) and superoxide dismutase (SOD) levels in kidney and heart.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Potential Oxidative Stress in Egyptian Patients with Acute Zinc Phosphide Poisoning and the Role of Vitamin C

Sagah

Oreby

Elgharabawy³

et al. 2015

IJHS

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Objective: To evaluate potential oxidative stress in patients with acute phosphide poisoning and the effect of vitamin C. Methods:Participants were females and divided into three groups; group I: healthy volunteers group II: healthy volunteers received vitamin C, group III: patients with acute phosphide poisoning received the supportive and symptomatic treatment and group IV: patients with acute phosphide poisoning received the supportive and symptomatic treatment in addition to vitamin C. All the participants were subjected to thorough history, clinical examination, ECG and laboratory investigations were carried on collected blood and gastric lavage samples on admission. Blood samples were divided into two parts, one for measurement of routine investigations and the second part was used for evaluation of malondialdehyde and total thiol levels before and after receiving the treatment regimen.Results: Most of the cases in this study were among the age group of 15-25 years, females, single, secondary school education, from rural areas and suicidal. All vital signs were within normal range and the most common complaint was vomiting and abdominal pain. All cases in this study showed normal routine investigations. The mean MDA levels after receiving treatment decreased significantly in groups II and IV. The mean total thiol levels increased significantly after receiving treatment in groups II and IV. Conclusion:It can be concluded that vitamin C has a potential benefit due to its antioxidant property on zinc phosphide induced-oxidative stress in acute zinc phosphide poisoned patients.

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“…According to an article published in 2016, more aggressive gastrointestinal decontamination is necessary for patients [4]. Different studies in rats [14] and humans [15] have revealed that N-acetylcysteine can help as it replenishes cellular glutathione and magnesium, in addition to its antioxidant properties. In rats exposed to AlP, N-acetylcysteine increased survival time and reduced myocardial oxidative injury [15].…”

Section: Discussionmentioning

confidence: 99%

Successful management of zinc phosphide poisoning: possible benefit of virgin olive oil

Altıntop¹,

Tatlı²

2017

Med-Science

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Metal phosphides in general and zinc phosphide, in particular, are potent insecticides and rodenticides. These are commercially used for protection of crops during storage, as well as during transportation. However, these are highly toxic substances. Zinc phosphide (Zn2P3) and other phosphides are generally misused intentionally for suicidal purpose in Turkey. While most fatal PH3 exposures are unintentional, metal phosphide pellet ingestion has been used intentionally as a means of suicide in several Asian countries and in Europe. Once ingested, zinc phosphide is decomposed into highly toxic phosphine gas by the action of a dilute hydrochloric acid content of the stomach. Phosphine acts as a respiratory poison. Even 20:100,000 part of phosphine in the air is reported to fatal. Their detrimental effects may range from nausea and headache to renal failure and death. It's poisoning has a high mortality and recent years have seen an increase in the number of poisoning cases and deaths caused by suicidal ingestion. In episodes of metal phosphide poisoning, the treatment depends on the route of exposure. We aimed to present an intentionally ingested Zn2P3 of 15 g patient on suicide purpose and our therapy with orally NaHCO3, activated charcoal and virgin olive oil. In our case, we used repeated doses of virgin olive oil to induce antioxidant activity beside the recommended therapy regimens. Interestingly, the patient presented only mild symptoms of toxicity such as transient metabolic acidosis and hepatic dysfunction.

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Phosphine-induced oxidative damage in rats: role of glutathione

Cited by 118 publications

References 37 publications

Study of laboratory profile in patients with aluminium phosphide poisoning in the southwest of Iran from 2010 to 2015

Study of laboratory profile in patients with aluminium phosphide poisoning in the southwest of Iran from 2010 to 2015

Evaluation of Potential Oxidative Stress in Egyptian Patients with Acute Zinc Phosphide Poisoning and the Role of Vitamin C

Successful management of zinc phosphide poisoning: possible benefit of virgin olive oil

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