Phosphatidylserine-containing liposomes: Therapeutic potentials against hypercholesterolemia and atherosclerosis

Naeini, Mehri Bemani; Momtazi‐Borojeni, Amir Abbas; Ganjali, Shiva; Kontush, Anatol; Jaafari, Mahmoud Reza; Sahebkar, Amirhossein

doi:10.1016/j.ejphar.2021.174308

Cited by 5 publications

(4 citation statements)

References 74 publications

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“…The interaction between the phospholipid and SPI can be achieved in a variety of ways, including hydrophobic and electrostatic interactions [20] . Phosphatidylserine (PS) is a natural phospholipid with an irreplaceable role in biological cell membranes, showing great physicochemical properties and biological activity, and has been used in the preparation of mixed micelles [21] , nanodispersions [22] , and liposomes [23] . PS has a negatively charged head.…”

Section: Introductionmentioning

confidence: 99%

Effect of ultrasound on the structural characteristics and oxidative stability of walnut oil oleogel coated with soy protein isolate-phosphatidylserine

Wang

Gong

et al. 2022

Ultrasonics Sonochemistry

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Section: Introductionmentioning

confidence: 99%

Effect of ultrasound on the structural characteristics and oxidative stability of walnut oil oleogel coated with soy protein isolate-phosphatidylserine

Wang

Gong

et al. 2022

Ultrasonics Sonochemistry

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“…To prove Mφ is detrimental Silica dust (Blight 1985) Exert cytotoxic effects to Mφ Less myelin axons and less vascularization in the lesion Clodronate (Popovich 1999) Deplete peripheral Mφ Decreased the tissue cavity and promoted motor function Anti-CD11d mAb (Gris 2004) Block the interaction between endothelial cell and hematogenous Mφ Increasing density of neurofilament axon Anti-αDβ2 mAb (Mabon 2000;Naeini et al, 2021) Block the connection of αDβ2-VCAM-1 Less necrotic debris and long-lasting sensorimotor function recovery Adiponectin Suppress myelin lipid accumulation Reduced myelin lipid accumulation and impaired neurogenesis To prove Mφ is beneficial C5a (Dander et al, 2021) Induce epicenter-directed macrophage migration Avoid neuron contact and reduce incidence of axonal dieback Transplantation (Han et al, 2021) Transfer…”

Section: Objective Treatment Experimental Principle Resultsmentioning

confidence: 99%

Hematogenous Macrophages: A New Therapeutic Target for Spinal Cord Injury

Ding

Zhang

Wang

et al. 2021

Front. Cell Dev. Biol.

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Spinal cord injury (SCI) is a devastating disease leading to loss of sensory and motor functions, whose pathological process includes mechanical primary injury and secondary injury. Macrophages play an important role in SCI pathology. According to its origin, it can be divided into resident microglia and peripheral monocyte-derived macrophages (hematogenous Mφ). And it can also be divided into M1-type macrophages and M2-type macrophages on the basis of its functional characteristics. Hematogenous macrophages may contribute to the SCI process through infiltrating, scar forming, phagocytizing debris, and inducing inflammatory response. Although some of the activities of hematogenous macrophages are shown to be beneficial, the role of hematogenous macrophages in SCI remains controversial. In this review, following a brief introduction of hematogenous macrophages, we mainly focus on the function and the controversial role of hematogenous macrophages in SCI, and we propose that hematogenous macrophages may be a new therapeutic target for SCI.

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“…Ceramide is the key metabolite of sphingomyelin metabolism. Its biological functions primarily include inducing apoptosis ( Toshima et al, 2019 ; Partoazar et al, 2021 ), regulating cell differentiation ( Naeini et al, 2021 ), regulating cellular immunity, and participating in regulating inflammatory response ( Aragón-Aranda et al, 2021 ). Our results revealed that berberine could significantly decrease LysoPC levels, which indicated that berberine could significantly prevent LPS-induced systemic inflammation by regulating the abnormal phospholipid metabolic pathway.…”

Section: Discussionmentioning

confidence: 99%

Metabolomics profiling reveals berberine-inhibited inflammatory response in human gingival fibroblasts by regulating the LPS-induced apoptosis signaling pathway

Zhang

Guo²,

Wei³

et al. 2022

Front. Pharmacol.

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This article examines berberine’s biological effects and molecular mechanisms with an inflammatory response model induced by lipopolysaccharide (LPS) in human gingival fibroblasts (HGFs) using metabolomics. The viability of HGFs was determined using the cell counting kit-8 (CCK8). ELISA was used to measure inflammatory cytokines, including interleukin-6 (IL-6), interleukin-1β (IL-1β), and tumor necrosis factor- α (TNF-α). An investigation of western blots was conducted to investigate the related proteins of apoptosis. Low concentrations of berberine (0.1, 0.5, and 1 μmol L−1) did not affect HGF growth, whereas high concentrations of berberine (5–25 μmol L−1) significantly activated cell proliferation. Berberine suppressed the elevated secretion of IL-6, IL-1β, and TNF-α induced by LPS in HGF. Western blot analysis showed that 10 μmol L−1 of berberine significantly inhibited LPS-induced apoptosis signaling pathway activation. Our results suggested that berberine could inhibit LPS-induced apoptosis and the production of proinflammatory mediators in HGFs cells. Berberine may be a potential therapeutic drug for the management of periodontitis.

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Phosphatidylserine-containing liposomes: Therapeutic potentials against hypercholesterolemia and atherosclerosis

Cited by 5 publications

References 74 publications

Effect of ultrasound on the structural characteristics and oxidative stability of walnut oil oleogel coated with soy protein isolate-phosphatidylserine

Effect of ultrasound on the structural characteristics and oxidative stability of walnut oil oleogel coated with soy protein isolate-phosphatidylserine

Hematogenous Macrophages: A New Therapeutic Target for Spinal Cord Injury

Metabolomics profiling reveals berberine-inhibited inflammatory response in human gingival fibroblasts by regulating the LPS-induced apoptosis signaling pathway

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