Phosphatidylserine clustering by membrane receptors triggers LC3-associated phagocytosis
Emilio Boada-Romero,
Clifford S. Guy,
Gustavo Palacios
et al.
Abstract:LC3-associated phagocytosis (LAP) represents a non-canonical function of autophagy proteins in which ATG8 family proteins (LC3 and GABARAP proteins) are lipidated onto single-membrane phagosomes as particles are engulfed by phagocytic cells. LAP plays roles in innate immunity, inflammation and anti-cancer responses and is initiated upon phagocytosis of particles that stimulate Toll-like receptors (TLR), Fc-receptors, and upon engulfment of dying cells. However, how this molecular route is initiated remains elu… Show more
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