Phosphatidylinositol-4-phosphate joins the dance of plant autophagosome formation

Gomez, Rodrigo Enrique; Castets, Julie; Lupette, Josselin; Chambaud, Clément; Joubès, Jérôme; Bernard, Amélie

doi:10.1080/15548627.2022.2132042

Cited by 3 publications

(2 citation statements)

References 1 publication

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“…Autophagic degradation of cellular components supports cell homeostasis under nutrient starvation. Autophagosome formation relies on membrane modeling and re-modeling events, from the nucleation of the phagophore to its expansion and closure [86]. Autophagy may play a role in response to P deprivation, which is associated with a decrease in energy-rich molecules such as ATP, and a range of phosphorylated metabolites [87,88].…”

Section: Phosphorus Starvationmentioning

confidence: 99%

“…The lipids associated with the autophagosome has started to be revealed in plants. While a new player in plant autophagosome formation appeared to be a negatively charged phosphatidylinositol-4-phosphate (PtdIns4P) [86], the lipid(s) involved in microalgal ATG8 lipidation is currently unknown. Because autophageous vacuoles decline with the duration of P starvation, we hypothesize that prolonged P deficiency depletes phospholipids required for the autophagy machinery and thus cells are unable to completely degrade polyP reserves.…”

Section: Phosphorus Starvationmentioning

confidence: 99%

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Getting Grip on Phosphorus: Potential of Microalgae as a Vehicle for Sustainable Usage of This Macronutrient

Solovchenko,

Plouviez,

Khozin-Goldberg

2024

Preprint

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Phosphorus (P) is an important and irreplaceable macronutrient. It is central to energy and information storage and exchange in living cell. P is an element with “broken geochemical cycle” since it lacks abundant volatile compounds capable of closing the P cycle. P fertilizers are critical for global food security, but the reserves of minable P are scarce and non-evenly distributed between countries of the world. Accordingly, the risks of global crisis due to limited access to P reserves is expected to be graver than those entailed by competition for fossil hydrocarbons. Paradoxically, despite the scarcity and value of P reserves, its usage is extremely inefficient: current waste rate reaches 80% giving rise to a plethora of unwanted consequences such as eutrophication leading to harmful algal blooms. Microalgal biotechnology comprise a promising solution to tackle this challenge. The proposed review briefly presents the relevant aspects of microalgal P metabolism such as cell P reserve composition and turnover, and the regulation of P uptake kinetics for maximization of P uptake efficiency with the focus on novel knowledge. Multifaceted role of polyPhosphates, the largest cell depot for P, is discussed with emphasis on the P toxicity mediated by short-chain polyPhosphates. Opportunities and hurdles of P bioremoval via P uptake from waste streams with microalgal cultures, either suspended or immobilized, is discussed along with the role of bacterial components of microalgal-bacterial consortia in these processes. Possible avenues of P-rich microalgal biomass such as biofertilizer production or extraction of valuable polyPhosphates and other bioproducts are considered. The review concludes with a comprehensive assessment of the current potential of microalgal biotechnology for ensuring the sustainable usage of phosphorus.

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Section: Phosphorus Starvationmentioning

confidence: 99%

Section: Phosphorus Starvationmentioning

confidence: 99%

Getting Grip on Phosphorus: Potential of Microalgae as a Vehicle for Sustainable Usage of This Macronutrient

Solovchenko,

Plouviez,

Khozin-Goldberg

2024

Preprint

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Aberrant accumulation of ceramides in mitochondria triggers cell death by inducing autophagy in Arabidopsis

Bao,

Yin,

Wang

et al. 2023

Journal of Experimental Botany

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Sphingolipids are membrane lipids and play critical roles in signal transduction. Ceramides are central components of sphingolipid metabolism that are involved in cell death. However, the mechanism of ceramides regulating cell death in plants remains unclear. Here, we found that ceramides accumulated in mitochondria of accelerated cell death 5 mutant (acd5), and expression of mitochondrion-localized ceramide kinase (ACD5) suppressed mitochondrial ceramide accumulation and the acd5 cell death phenotype. Using immuno-electron microscopy, we observed hyperaccumulation of ceramides in acer acd5 double mutants, which are characterized by mutations in both ACER (alkaline ceramidase) and ACD5 genes. The results confirmed that plants with specific ceramide accumulation exhibited localization of ceramides to mitochondria, resulting in an increase in mitochondrial reactive oxygen species production. Interestingly, when compared with the wild type, autophagy-deficient mutants showed stronger resistance to ceramide-induced cell death. Lipid profiling analysis demonstrated that plants with ceramide accumulation exhibited a significant increase in phosphatidylethanolamine levels. Furthermore, exogenous ceramide treatment or endogenous ceramide accumulation induces autophagy. When exposed to exogenous ceramides, an increase in the level of the autophagy-specific ubiquitin-like protein, ATG8e, associated with mitochondria, where it directly bound to ceramides. Taken together, we propose that the accumulation of ceramides in mitochondria can induce cell death by regulating autophagy.

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Getting Grip on Phosphorus: Potential of Microalgae as a Vehicle for Sustainable Usage of This Macronutrient

Solovchenko,

Plouviez,

Khozin-Goldberg

2024

Plants

View full text Add to dashboard Cite

Phosphorus (P) is an important and irreplaceable macronutrient. It is central to energy and information storage and exchange in living cells. P is an element with a “broken geochemical cycle” since it lacks abundant volatile compounds capable of closing the P cycle. P fertilizers are critical for global food security, but the reserves of minable P are scarce and non-evenly distributed between countries of the world. Accordingly, the risks of global crisis due to limited access to P reserves are expected to be graver than those entailed by competition for fossil hydrocarbons. Paradoxically, despite the scarcity and value of P reserves, its usage is extremely inefficient: the current waste rate reaches 80% giving rise to a plethora of unwanted consequences such as eutrophication leading to harmful algal blooms. Microalgal biotechnology is a promising solution to tackle this challenge. The proposed review briefly presents the relevant aspects of microalgal P metabolism such as cell P reserve composition and turnover, and the regulation of P uptake kinetics for maximization of P uptake efficiency with a focus on novel knowledge. The multifaceted role of polyPhosphates, the largest cell depot for P, is discussed with emphasis on the P toxicity mediated by short-chain polyPhosphates. Opportunities and hurdles of P bioremoval via P uptake from waste streams with microalgal cultures, either suspended or immobilized, are discussed. Possible avenues of P-rich microalgal biomass such as biofertilizer production or extraction of valuable polyPhosphates and other bioproducts are considered. The review concludes with a comprehensive assessment of the current potential of microalgal biotechnology for ensuring the sustainable usage of phosphorus.

show abstract

Phosphatidylinositol-4-phosphate joins the dance of plant autophagosome formation

Cited by 3 publications

References 1 publication

Getting Grip on Phosphorus: Potential of Microalgae as a Vehicle for Sustainable Usage of This Macronutrient

Getting Grip on Phosphorus: Potential of Microalgae as a Vehicle for Sustainable Usage of This Macronutrient

Aberrant accumulation of ceramides in mitochondria triggers cell death by inducing autophagy in Arabidopsis

Getting Grip on Phosphorus: Potential of Microalgae as a Vehicle for Sustainable Usage of This Macronutrient

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